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- W2017088366 abstract "Abstract Rats given intracisternal administration of 5–6 dihydroxytryptamine (5,6 DHT) 5 days after birth were tested at two subsequent periods for alterations in locomotor activity and responsiveness to dl-amphetamine and scopolamine. Later in life they were given amphetamine while performing on an FR-6 operant schedule for food reward. Biochemical analyses revealed that the 5,6 DHT treatment produced reductions in forebrain serotonin content. There was no alteration in the treated animals in locomotor activity or in responsiveness to amphetamine in the open field. However, animals given the highest dose (75 μg) of 5,6 DHT neonatally showed open field activity increases at high doses of scopolamine significantly more frequently than the other groups of animals. Although treatment with 5,6 DHT did not affect response rates on the FR task under no-drug conditions, the rate-suppressive effects of amphetamine on the FR task were greatly enhanced in the treated animals." @default.
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- W2017088366 date "1977-07-01" @default.
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- W2017088366 title "Serotonin reduction early in life and its effects on behavior" @default.
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- W2017088366 doi "https://doi.org/10.1016/0024-3205(77)90304-6" @default.
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