FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2017091837> ?p ?o ?g. }

• W2017091837 endingPage "4470" @default.
• W2017091837 startingPage "4453" @default.
• W2017091837 abstract "Licorice is a traditional botanical medicine, and has historically been commonly prescribed in Asia to treat various diseases. Glycyrrhizin (Gc), a triterpene compound, is the most abundant phytochemical constituent of licorice. However, high intake or long-term consumption of Gc has been associated with a number of side effects, including hypertension. However, the presence of alternative bioactive compounds in licorice with anti-carcinogenic effects has long been suspected. Licochalcone A (LicoA) is a prominent member of the chalcone family and can be isolated from licorice root. To date, there have been no reported studies on the suppressive effect of LicoA against solar ultraviolet (sUV)-induced cyclooxygenase (COX)-2 expression and the potential molecular mechanisms involved. Here, we show that LicoA, a major chalcone compound of licorice, effectively inhibits sUV-induced COX-2 expression and prostaglandin E2 PGE2 generation through the inhibition of activator protein 1 AP-1 transcriptional activity, with an effect that is notably more potent than Gc. Western blotting analysis shows that LicoA suppresses sUV-induced phosphorylation of Akt/ mammalian target of rapamycin (mTOR) and extracellular signal-regulated kinases (ERK)1/2/p90 ribosomal protein S6 kinase (RSK) in HaCaT cells. Moreover, LicoA directly suppresses the activity of phosphoinositide 3-kinase (PI3K), mitogen-activated protein kinase kinase (MEK)1, and B-Raf, but not Raf-1 in cell-free assays, indicating that PI3K, MEK1, and B-Raf are direct molecular targets of LicoA. We also found that LicoA binds to PI3K and B-Raf in an ATP-competitive manner, although LicoA does not appear to compete with ATP for binding with MEK1. Collectively, these results provide insight into the biological action of LicoA, which may have potential for development as a skin cancer chemopreventive agent." @default.
• W2017091837 created "2016-06-24" @default.
• W2017091837 creator A5000045048 @default.
• W2017091837 creator A5003136662 @default.
• W2017091837 creator A5006050449 @default.
• W2017091837 creator A5020793305 @default.
• W2017091837 creator A5045877476 @default.
• W2017091837 creator A5050507605 @default.
• W2017091837 creator A5067249774 @default.
• W2017091837 creator A5073008436 @default.
• W2017091837 creator A5076987585 @default.
• W2017091837 creator A5079211189 @default.
• W2017091837 creator A5081266897 @default.
• W2017091837 date "2015-02-20" @default.
• W2017091837 modified "2023-09-24" @default.
• W2017091837 title "Licochalcone A, a Polyphenol Present in Licorice, Suppresses UV-Induced COX-2 Expression by Targeting PI3K, MEK1, and B-Raf" @default.
• W2017091837 cites W1687972305 @default.
• W2017091837 cites W1845493419 @default.
• W2017091837 cites W1963564374 @default.
• W2017091837 cites W1965770535 @default.
• W2017091837 cites W1979600905 @default.
• W2017091837 cites W1980552145 @default.
• W2017091837 cites W1996405087 @default.
• W2017091837 cites W2003021270 @default.
• W2017091837 cites W2006922785 @default.
• W2017091837 cites W2011814013 @default.
• W2017091837 cites W2012579173 @default.
• W2017091837 cites W2015217355 @default.
• W2017091837 cites W2016560102 @default.
• W2017091837 cites W2017717405 @default.
• W2017091837 cites W2019518392 @default.
• W2017091837 cites W2021122120 @default.
• W2017091837 cites W2026825780 @default.
• W2017091837 cites W2027115060 @default.
• W2017091837 cites W2034014920 @default.
• W2017091837 cites W2037587486 @default.
• W2017091837 cites W2038043449 @default.
• W2017091837 cites W2042660701 @default.
• W2017091837 cites W2058118671 @default.
• W2017091837 cites W2063130673 @default.
• W2017091837 cites W2064283997 @default.
• W2017091837 cites W2064531062 @default.
• W2017091837 cites W2068063680 @default.
• W2017091837 cites W2076754005 @default.
• W2017091837 cites W2077232152 @default.
• W2017091837 cites W2079412054 @default.
• W2017091837 cites W2092129219 @default.
• W2017091837 cites W2094544968 @default.
• W2017091837 cites W2096801003 @default.
• W2017091837 cites W2097661112 @default.
• W2017091837 cites W2107916749 @default.
• W2017091837 cites W2108792989 @default.
• W2017091837 cites W2115635275 @default.
• W2017091837 cites W2124921409 @default.
• W2017091837 cites W2128100003 @default.
• W2017091837 cites W2130417112 @default.
• W2017091837 cites W2147996172 @default.
• W2017091837 cites W2162037098 @default.
• W2017091837 cites W2367609048 @default.
• W2017091837 cites W2388163742 @default.
• W2017091837 cites W2416021374 @default.
• W2017091837 cites W2417914870 @default.
• W2017091837 cites W2418241258 @default.
• W2017091837 cites W2442868047 @default.
• W2017091837 cites W845868967 @default.
• W2017091837 cites W90050409 @default.
• W2017091837 doi "https://doi.org/10.3390/ijms16034453" @default.
• W2017091837 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4394430" @default.
• W2017091837 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25710724" @default.
• W2017091837 hasPublicationYear "2015" @default.
• W2017091837 type Work @default.
• W2017091837 sameAs 2017091837 @default.
• W2017091837 citedByCount "31" @default.
• W2017091837 countsByYear W20170918372015 @default.
• W2017091837 countsByYear W20170918372016 @default.
• W2017091837 countsByYear W20170918372017 @default.
• W2017091837 countsByYear W20170918372018 @default.
• W2017091837 countsByYear W20170918372019 @default.
• W2017091837 countsByYear W20170918372020 @default.
• W2017091837 countsByYear W20170918372021 @default.
• W2017091837 countsByYear W20170918372022 @default.
• W2017091837 countsByYear W20170918372023 @default.
• W2017091837 crossrefType "journal-article" @default.
• W2017091837 hasAuthorship W2017091837A5000045048 @default.
• W2017091837 hasAuthorship W2017091837A5003136662 @default.
• W2017091837 hasAuthorship W2017091837A5006050449 @default.
• W2017091837 hasAuthorship W2017091837A5020793305 @default.
• W2017091837 hasAuthorship W2017091837A5045877476 @default.
• W2017091837 hasAuthorship W2017091837A5050507605 @default.
• W2017091837 hasAuthorship W2017091837A5067249774 @default.
• W2017091837 hasAuthorship W2017091837A5073008436 @default.
• W2017091837 hasAuthorship W2017091837A5076987585 @default.
• W2017091837 hasAuthorship W2017091837A5079211189 @default.
• W2017091837 hasAuthorship W2017091837A5081266897 @default.
• W2017091837 hasBestOaLocation W20170918371 @default.
• W2017091837 hasConcept C104202773 @default.
• W2017091837 hasConcept C11960822 @default.
• W2017091837 hasConcept C142724271 @default.

• next