Matches in SemOpenAlex for { <https://semopenalex.org/work/W2017092272> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W2017092272 endingPage "71" @default.
- W2017092272 startingPage "64" @default.
- W2017092272 abstract "The cystic fibrosis transmembrane conductance regulator (CFTR) inhibits epithelial Na(+) channels (ENaC). Evidence has accumulated that both Cl(-) transport through CFTR Cl(-) channels and the first nucleotide binding domain (NBF1) of CFTR are crucial for inhibition of ENaC. A PDZ binding domain (PDZ-BD) at the C-terminal end links CFTR to scaffolding and cytoskeletal proteins, which have been suggested to play an important role in activation of CFTR and eventually inhibition of ENaC. We eliminated the PDZ-BD of CFTR and coexpressed Na(+)/H(+)-exchange regulator factors together with CFTR and ENaC. The results do not support a role of PDZ-BD in inhibition of ENaC by CFTR. However, inhibition of ENaC was closely linked to Cl(-) currents generated by CFTR and was observed in the presence of Cl(-), I(-) or Br(-) but not gluconate. Therefore, functional NBF1 and Cl(-) transport are required for inhibition of ENaC in Xenopus oocytes, while the PDZ-BD is not essential." @default.
- W2017092272 created "2016-06-24" @default.
- W2017092272 creator A5008491806 @default.
- W2017092272 creator A5037554008 @default.
- W2017092272 creator A5051912802 @default.
- W2017092272 date "2001-11-01" @default.
- W2017092272 modified "2023-09-27" @default.
- W2017092272 title "Role of CFTR’s PDZ1-binding domain, NBF1 and Cl− conductance in inhibition of epithelial Na+ channels in Xenopus oocytes" @default.
- W2017092272 cites W1954895018 @default.
- W2017092272 cites W1965144258 @default.
- W2017092272 cites W1971812877 @default.
- W2017092272 cites W1973901120 @default.
- W2017092272 cites W1983860827 @default.
- W2017092272 cites W1991550774 @default.
- W2017092272 cites W2005443663 @default.
- W2017092272 cites W2010905437 @default.
- W2017092272 cites W2023681929 @default.
- W2017092272 cites W2033335450 @default.
- W2017092272 cites W2051446765 @default.
- W2017092272 cites W2057032201 @default.
- W2017092272 cites W2057772810 @default.
- W2017092272 cites W2057831448 @default.
- W2017092272 cites W2061780012 @default.
- W2017092272 cites W2066318082 @default.
- W2017092272 cites W2077640402 @default.
- W2017092272 cites W2081983733 @default.
- W2017092272 cites W2085837097 @default.
- W2017092272 cites W2087997490 @default.
- W2017092272 cites W2088295492 @default.
- W2017092272 cites W2101496432 @default.
- W2017092272 cites W2132471653 @default.
- W2017092272 cites W2141240174 @default.
- W2017092272 cites W2247924904 @default.
- W2017092272 cites W2259743896 @default.
- W2017092272 cites W2329733014 @default.
- W2017092272 cites W2413162168 @default.
- W2017092272 cites W4233060341 @default.
- W2017092272 doi "https://doi.org/10.1016/s0005-2736(01)00396-0" @default.
- W2017092272 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11597353" @default.
- W2017092272 hasPublicationYear "2001" @default.
- W2017092272 type Work @default.
- W2017092272 sameAs 2017092272 @default.
- W2017092272 citedByCount "22" @default.
- W2017092272 countsByYear W20170922722019 @default.
- W2017092272 countsByYear W20170922722020 @default.
- W2017092272 countsByYear W20170922722021 @default.
- W2017092272 crossrefType "journal-article" @default.
- W2017092272 hasAuthorship W2017092272A5008491806 @default.
- W2017092272 hasAuthorship W2017092272A5037554008 @default.
- W2017092272 hasAuthorship W2017092272A5051912802 @default.
- W2017092272 hasConcept C104317684 @default.
- W2017092272 hasConcept C12554922 @default.
- W2017092272 hasConcept C153911025 @default.
- W2017092272 hasConcept C154428179 @default.
- W2017092272 hasConcept C178790620 @default.
- W2017092272 hasConcept C185592680 @default.
- W2017092272 hasConcept C2778428886 @default.
- W2017092272 hasConcept C2779535977 @default.
- W2017092272 hasConcept C537181965 @default.
- W2017092272 hasConcept C55493867 @default.
- W2017092272 hasConcept C6507245 @default.
- W2017092272 hasConcept C86803240 @default.
- W2017092272 hasConcept C95444343 @default.
- W2017092272 hasConceptScore W2017092272C104317684 @default.
- W2017092272 hasConceptScore W2017092272C12554922 @default.
- W2017092272 hasConceptScore W2017092272C153911025 @default.
- W2017092272 hasConceptScore W2017092272C154428179 @default.
- W2017092272 hasConceptScore W2017092272C178790620 @default.
- W2017092272 hasConceptScore W2017092272C185592680 @default.
- W2017092272 hasConceptScore W2017092272C2778428886 @default.
- W2017092272 hasConceptScore W2017092272C2779535977 @default.
- W2017092272 hasConceptScore W2017092272C537181965 @default.
- W2017092272 hasConceptScore W2017092272C55493867 @default.
- W2017092272 hasConceptScore W2017092272C6507245 @default.
- W2017092272 hasConceptScore W2017092272C86803240 @default.
- W2017092272 hasConceptScore W2017092272C95444343 @default.
- W2017092272 hasIssue "1" @default.
- W2017092272 hasLocation W20170922721 @default.
- W2017092272 hasLocation W20170922722 @default.
- W2017092272 hasOpenAccess W2017092272 @default.
- W2017092272 hasPrimaryLocation W20170922721 @default.
- W2017092272 hasRelatedWork W1626140540 @default.
- W2017092272 hasRelatedWork W2017092272 @default.
- W2017092272 hasRelatedWork W2025791067 @default.
- W2017092272 hasRelatedWork W2110464131 @default.
- W2017092272 hasRelatedWork W2256490943 @default.
- W2017092272 hasRelatedWork W2560225360 @default.
- W2017092272 hasRelatedWork W270374260 @default.
- W2017092272 hasRelatedWork W3175981154 @default.
- W2017092272 hasRelatedWork W4303199205 @default.
- W2017092272 hasRelatedWork W4316127160 @default.
- W2017092272 hasVolume "1515" @default.
- W2017092272 isParatext "false" @default.
- W2017092272 isRetracted "false" @default.
- W2017092272 magId "2017092272" @default.
- W2017092272 workType "article" @default.