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- W2017092318 abstract "A synthetic method for the preparation of suitably protected 3-carboxy-Δ2-pyrazolin-5-yl-alanine was developed. This scaffold is amenable to further decoration at the N1 position and was used to generate novel NMDA receptor ligands. Although weaker than the previously reported N1-Ph derivatives, the new ligands retain the ability to selectively bind to NMDA receptor with micromolar to submicromolar affinity. Considering the relevance of the N-functionalization for the biological activity, the results presented in this communication are preliminary to a full SAR study of this novel class of NMDA receptor antagonists." @default.
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- W2017092318 date "2013-10-01" @default.
- W2017092318 modified "2023-10-13" @default.
- W2017092318 title "3-Carboxy-pyrazolinalanine as a new scaffold for developing potent and selective NMDA receptor antagonists" @default.
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- W2017092318 doi "https://doi.org/10.1016/j.ejmech.2013.07.010" @default.
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