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• W2017092598 startingPage "91" @default.
• W2017092598 abstract "Repeated exposure to addictive drugs results in long-lasting neuroadaptations in the brain, especially in the mesocorticolimbic system. Within this system, the nucleus accumbens (NAc) plays a major integrative role. As such, the NAc has been shown to be a target of short- and long-lasting drug-induced neuroadaptations at the levels of neurotransmission and cellular morphology. The long-lasting neuroadaptations might depend critically on alterations in gene expression. Recently, we obtained a set of transcripts by means of subtractive hybridization, of which the expression was decreased in the rat NAc shell after long-term extinction of intravenous heroin self-administration. Interestingly, the majority of these transcripts were also down-regulated upon long-term extinction of cocaine self-administration. Using the yoked-control operant paradigm, it was shown that non-contingent administration of these drugs resulted in a totally different gene expression profile. However, in the rat NAc core, both self-administration and non-contingent heroin administration induced a qualitatively similar expression profile. Hence, cognitive processes associated with drug self-administration seem to direct the long-term genomic responses in the NAc shell, whereas the NAc core might primarily mediate the persistent pharmacological effects of addictive drugs (including Pavlovian conditioning)." @default.
• W2017092598 created "2016-06-24" @default.
• W2017092598 creator A5028754896 @default.
• W2017092598 creator A5029767483 @default.
• W2017092598 creator A5046661343 @default.
• W2017092598 creator A5061197527 @default.
• W2017092598 date "2005-03-01" @default.
• W2017092598 modified "2023-10-16" @default.
• W2017092598 title "Long-Term Gene Expression in the Nucleus Accumbens Following Heroin Administration is Subregion-Specific and Depends on the Nature of Drug Administration" @default.
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• W2017092598 doi "https://doi.org/10.1080/13556210412331284748" @default.
• W2017092598 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15849023" @default.
• W2017092598 hasPublicationYear "2005" @default.
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