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- W2017100851 abstract "Atopy (a predisposition of the immune system toward allergic disorders including asthma) has increased dramatically in the US in the last twenty years. Epidemiological studies have found body mass index (body weight kg/height m2) to be a positive independent correlate of atopy in women and not men. The effect of habitual physical activity (HPA) on this relationship is not known. PURPOSE Investigate the prevalence of atopy among healthy obese (OB) and non-obese (NO) women and its relationship to fat mass (FM), insulin resistance (IR), plasma concentrations of 17 β-estradiol (E), IL-4 and leptin, and HPA. METHODS A cross-sectional study of 21 OB (>30% body fat) and 22 NO (<30% body fat) women (18–41y) was performed. The following measurements were taken: FM by plethysmography; atopy by Phadiatop® blood glucose, insulin, C-peptide, E, sex hormone binding globulin (SHBG), and IL-4, using commercial kits. Insulin sensitivity was determined using fasting insulin resistance index (FIRI) and by oral glucose tolerance test. Information about HPA was obtained through self-administered Baecke questionnaires, which have been shown to be valid and reliable for measurement of HPA in epidemiological studies. RESULTS Frequency of atopy was almost three times higher among OB than NO (p=0.008). Plasma concentrations of E (P=0.06), ratio of E:SHBG (P=0.02), and leptin (P<0.001) were higher among OB vs NO women. FIRI and C-peptide were higher among OB than NO (p<0.05) after adjustment for oral contraceptive use. All factors correlated positively with FM. No statistical differences in HPA were found (p=0.291), but OB tended to have lower scores, indicative of lower HPA. Logistic regression showed FM to be the only positive predictor of atopy (P=0.01); leptin tended to correlate negatively (P=0.06). CONCLUSIONS Findings show for the first time, a direct effect of adiposity on atopy in women. Percentage body fat mass may be a determinant of allergy and asthma development in women. Although self-reported HPA did not appear to be independently related to atopy, further study is necessary to determine the effect of duration and intensity of exercise on the relationship between adiposity and atopy in women." @default.
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- W2017100851 date "2005-05-01" @default.
- W2017100851 modified "2023-09-27" @default.
- W2017100851 title "Elevated Atopy Among Obese Women Not Related To Habitual Physical Activity" @default.
- W2017100851 doi "https://doi.org/10.1097/00005768-200505001-01953" @default.
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