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• W2017101209 abstract "CD81 protein has been shown to bind hepatitis C virus (HCV) envelope 2 (E2) glycoprotein in vitro and may act as a (co)receptor for HCV. Regulation of CD81 expression by interferon alfa (IFN-α) and ribavirin could thereby affect the response to antiviral therapy. In the present study, the effects of IFN-α and ribavirin on CD81 protein and CD81 mRNA were assessed in peripheral blood lymphocytes (PBL) and isolated human hepatocytes by fluorescence-activated cell sorter (FACS) analysis and real-time polymerase chain reaction (PCR), respectively. In addition, regulation of CD81 in PBL was investigated in 10 patients treated with combination therapy. Incubation with IFN-α (50 U/mL) down-regulated total CD81 in PBL (81.7 ± 11.6% of control; P = .003) and in isolated human hepatocytes (91.6 ± 8.1% of control; P = .034). Incubation with IFN-α with and without ribavirin (2.2 μg/mL) significantly reduced cell surface–associated CD81 protein (83.9 ± 10.3% of control; P = .003). PBL of untreated patients chronically infected with HCV had significantly higher levels of total CD81 protein compared with PBL obtained from healthy donors (631.1 ± 93.3 vs. 538.9 ± 95.2 relative fluorescence units [RFU]; P = .030). Pretreatment cell surface–associated CD81 protein was lower in patients infected with genotype HCV-3 than those infected with HCV-1 (111.8 ± 15.0 vs. 162.0 ± 41.3 RFU; P = .019). Furthermore, cell surface–associated CD81 protein was lower 4 weeks after initiation of therapy in patients with an initial virologic response compared with initial virologic nonresponders (110.5 ± 8.5 vs. 139.8 ± 27.5 RFU; P = .057). In conclusion, IFN-α and ribavirin regulate CD81 expression in vitro and in vivo. CD81 expression correlates with HCV genotype and initial virologic response in patients with chronic hepatitis C." @default.
• W2017101209 created "2016-06-24" @default.
• W2017101209 creator A5090681716 @default.
• W2017101209 date "2001-06-01" @default.
• W2017101209 modified "2023-10-12" @default.
• W2017101209 title "Interferon alfa down-regulates CD81 in patients with chronic hepatitis C" @default.
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• W2017101209 doi "https://doi.org/10.1053/jhep.2001.24668" @default.
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