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• W2017103519 startingPage "697" @default.
• W2017103519 abstract "In S. cerevisiae cells undergoing anaphase, a ras-related GTPase, Tem1, is located on the spindle pole body that enters the daughter cell and activates a signal transduction pathway, MEN, to allow mitotic exit. MEN activation must be reversed after mitotic exit to reset the cell cycle in G1. We find that daughter cells activate an Antagonist of MEN pathway (AMEN) in part through induction of the Amn1 protein that binds directly to Tem1 and prevents its association with its target kinase Cdc15. Failure of Amn1 function results in defects of both the spindle assembly and nuclear orientation checkpoints and delays turning off Cdc14 in G1. Thus, Amn1 is part of a daughter-specific switch that helps cells exit from mitotic exit and reset the cell cycle." @default.
• W2017103519 created "2016-06-24" @default.
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• W2017103519 date "2003-03-01" @default.
• W2017103519 modified "2023-09-26" @default.
• W2017103519 title "Exit from Exit" @default.
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• W2017103519 doi "https://doi.org/10.1016/s0092-8674(03)00121-1" @default.
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