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- W2017109410 abstract "OWING to marked individual variations in the rate of metabolic transformation in man, the daily doses of phenylbutazone used in therapy show a relatively wide range. Burns et al.1 found a biological half-life for phenylbutazone ranging from 1.5 to 6 days, and correspondingly found plateau plasma concentrations ranging from 60 to 150 mg/1. in different individuals. After an initial dose of 800 mg orally followed by 200 mg four times daily, Wilson et al.2 found plasma concentrations from 50 to 100 mg/1. and consider these concentrations necessary for therapeutic effect. Currie3 found 80–110 mg/1. at the beginning of the therapy and later under maintenance dose-levels of 46–80 mg/l. Bruck et al.1 are of the opinion that, in order to avoid side-effects, plasma concentrations should not exceed 100 mg/l., and during treatment they maintained concentrations of between 50 and 90 mg/1. They propose that treatment should begin with 200 mg per day orally, and that the dose should increase by 100 mg daily until the response is satisfactory." @default.
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- W2017109410 date "1966-01-01" @default.
- W2017109410 modified "2023-10-17" @default.
- W2017109410 title "Serum Concentration of Phenylbutazone in Tests for Antiphlogistic Activity and under Clinical Treatment" @default.
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- W2017109410 doi "https://doi.org/10.1038/209519a0" @default.
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