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• W2017111180 abstract "Conditioned taste aversion (CTA) is a form of aversive memory in which an association is made between a consumed substance and a subsequent malaise. CTA is a critical mechanism for the successful survival, and hence evolution, of most animal species. The role of excitatory neurotransmitters in the neurochemical mechanisms of CTA is well recognized; however, less is known about the involvement of inhibitory receptor systems. In particular, the potential functions of metabotropic GABA B receptors in CTA have not yet been fully explored. GABA B receptors are metabotropic GABA receptors that are comprised of two subunits, GABA B(1) and GABA B(2) , which form heterodimers. The Gabbr1 gene is transcribed into two predominant isoforms, GABA B(1a) and GABA B(1b) , which differ in sequence primarily by the inclusion of a pair of sushi domains (also known as short consensus repeats) in the GABA B(1a) N terminus. The behavioral function of mammalian GABA B(1) receptor isoforms is currently unknown. Here, using a point mutation strategy in mice, we demonstrate that these two GABA B(1) receptor isoforms are differentially involved in critical components of CTA. In contrast to GABA B(1b) −/− and wild-type mice, GABA B(1a) −/− mice failed to acquire CTA. In contrast, GABA B(1b) −/− mice robustly acquired CTA but failed to show any extinction of this aversion. The data demonstrate that GABA B receptors are involved in both the acquisition and extinction of CTA; however, receptors containing the GABA B(1a) or the GABA B(1b) isoform differentially contribute to the mechanisms used to learn and remember the salience of aversive stimuli." @default.
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• W2017111180 date "2006-08-23" @default.
• W2017111180 modified "2023-09-23" @default.
• W2017111180 title "GABA_B(1)Receptor Isoforms Differentially Mediate the Acquisition and Extinction of Aversive Taste Memories" @default.
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• W2017111180 doi "https://doi.org/10.1523/jneurosci.2076-06.2006" @default.
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