FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2017111278> ?p ?o ?g. }

• W2017111278 endingPage "7081" @default.
• W2017111278 startingPage "7071" @default.
• W2017111278 abstract "FtsZ polymerizes to form a cytokinetic ring at the center of a bacterial cell, which engineers bacterial cell division. FtsZ consists of N-terminal and C-terminal core domains followed by a C-terminal spacer and a conserved C-terminal tail region. Though it has been reported that both N- and C-domains can fold independently, the assembly behaviors of the N- and C-domains are not clear. In this study, we created five truncated constructs of Bacillus subtilis FtsZ, two N-domain and three C-domain constructs, and expressed and purified them. We determined their assembly properties and their effect on the assembly of full-length FtsZ to gain insight into the mechanism of FtsZ polymerization. We found that the N-domain of B. subtilis FtsZ can polymerize on its own in a GTP-dependent manner. Further, we obtained evidence indicating that the N-domain could bind to GTP but could not hydrolyze GTP by itself. In addition, the N-domain was found to inhibit the assembly of full-length FtsZ. Interestingly, the N-domain was found to enhance the GTPase activity of full-length FtsZ. An analysis of the effects of the N- and C-domains on FtsZ assembly indicated that the assembly of FtsZ might be directional. The work has provided new insight into the assembly characteristics of FtsZ domains and the mechanism of FtsZ polymerization." @default.
• W2017111278 created "2016-06-24" @default.
• W2017111278 creator A5014454708 @default.
• W2017111278 creator A5026724807 @default.
• W2017111278 date "2013-09-24" @default.
• W2017111278 modified "2023-10-16" @default.
• W2017111278 title "Understanding FtsZ Assembly: Cues from the Behavior of Its N- and C-Terminal Domains" @default.
• W2017111278 cites W1568415783 @default.
• W2017111278 cites W1896254721 @default.
• W2017111278 cites W1966041739 @default.
• W2017111278 cites W1972909853 @default.
• W2017111278 cites W1986181072 @default.
• W2017111278 cites W2004090749 @default.
• W2017111278 cites W2015328208 @default.
• W2017111278 cites W2015483172 @default.
• W2017111278 cites W2015642465 @default.
• W2017111278 cites W2016612127 @default.
• W2017111278 cites W2038277636 @default.
• W2017111278 cites W2044217069 @default.
• W2017111278 cites W2046404631 @default.
• W2017111278 cites W2051948984 @default.
• W2017111278 cites W2052749821 @default.
• W2017111278 cites W2072256706 @default.
• W2017111278 cites W2078040721 @default.
• W2017111278 cites W2082099401 @default.
• W2017111278 cites W2088677348 @default.
• W2017111278 cites W2089907517 @default.
• W2017111278 cites W2099393783 @default.
• W2017111278 cites W2105436135 @default.
• W2017111278 cites W2108596213 @default.
• W2017111278 cites W2121093284 @default.
• W2017111278 cites W2124514849 @default.
• W2017111278 cites W2132375330 @default.
• W2017111278 cites W2132629607 @default.
• W2017111278 cites W2135068654 @default.
• W2017111278 cites W2138717221 @default.
• W2017111278 cites W2140481794 @default.
• W2017111278 cites W2142155838 @default.
• W2017111278 cites W2143801691 @default.
• W2017111278 cites W2147458532 @default.
• W2017111278 cites W2151460035 @default.
• W2017111278 cites W2163498150 @default.
• W2017111278 cites W2168405431 @default.
• W2017111278 cites W2168985590 @default.
• W2017111278 cites W2324573217 @default.
• W2017111278 cites W4293247451 @default.
• W2017111278 doi "https://doi.org/10.1021/bi400129j" @default.
• W2017111278 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24007276" @default.
• W2017111278 hasPublicationYear "2013" @default.
• W2017111278 type Work @default.
• W2017111278 sameAs 2017111278 @default.
• W2017111278 citedByCount "7" @default.
• W2017111278 countsByYear W20171112782016 @default.
• W2017111278 countsByYear W20171112782017 @default.
• W2017111278 countsByYear W20171112782019 @default.
• W2017111278 countsByYear W20171112782021 @default.
• W2017111278 countsByYear W20171112782022 @default.
• W2017111278 crossrefType "journal-article" @default.
• W2017111278 hasAuthorship W2017111278A5014454708 @default.
• W2017111278 hasAuthorship W2017111278A5026724807 @default.
• W2017111278 hasConcept C118716 @default.
• W2017111278 hasConcept C12554922 @default.
• W2017111278 hasConcept C134306372 @default.
• W2017111278 hasConcept C142669718 @default.
• W2017111278 hasConcept C1491633281 @default.
• W2017111278 hasConcept C181199279 @default.
• W2017111278 hasConcept C185592680 @default.
• W2017111278 hasConcept C207332259 @default.
• W2017111278 hasConcept C2776237524 @default.
• W2017111278 hasConcept C2777272437 @default.
• W2017111278 hasConcept C33923547 @default.
• W2017111278 hasConcept C36503486 @default.
• W2017111278 hasConcept C523546767 @default.
• W2017111278 hasConcept C54355233 @default.
• W2017111278 hasConcept C55493867 @default.
• W2017111278 hasConcept C85813293 @default.
• W2017111278 hasConcept C86803240 @default.
• W2017111278 hasConcept C95444343 @default.
• W2017111278 hasConceptScore W2017111278C118716 @default.
• W2017111278 hasConceptScore W2017111278C12554922 @default.
• W2017111278 hasConceptScore W2017111278C134306372 @default.
• W2017111278 hasConceptScore W2017111278C142669718 @default.
• W2017111278 hasConceptScore W2017111278C1491633281 @default.
• W2017111278 hasConceptScore W2017111278C181199279 @default.
• W2017111278 hasConceptScore W2017111278C185592680 @default.
• W2017111278 hasConceptScore W2017111278C207332259 @default.
• W2017111278 hasConceptScore W2017111278C2776237524 @default.
• W2017111278 hasConceptScore W2017111278C2777272437 @default.
• W2017111278 hasConceptScore W2017111278C33923547 @default.
• W2017111278 hasConceptScore W2017111278C36503486 @default.
• W2017111278 hasConceptScore W2017111278C523546767 @default.
• W2017111278 hasConceptScore W2017111278C54355233 @default.
• W2017111278 hasConceptScore W2017111278C55493867 @default.
• W2017111278 hasConceptScore W2017111278C85813293 @default.
• W2017111278 hasConceptScore W2017111278C86803240 @default.
• W2017111278 hasConceptScore W2017111278C95444343 @default.
• W2017111278 hasIssue "40" @default.
• W2017111278 hasLocation W20171112781 @default.

• next