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- W2017112044 abstract "The vascular relaxant effects on isolated rat aorta of amlodipine camsylates (S-, R-enantiomer, and R/ S-racemate), were evaluated and compared with that of S-amlodipine besylate. Furthermore, antihypertensive effects were measured in spontaneously hypertensive rat (SHR). The S-amlodipine camsylate concentration-dependently inhibited Ca2+-induced contraction of rat aorta with a very slow onset of action (reached its maximum at 3.5h; ED50: 1.50 ± 0.24 nM), having a potency 2-fold higher than those of R/S-amlodipine camsylate (ED50: 3.36 ± 0.91 nM) and similar to those of S-amlodipine besylate (ED50: 1.44 ± 0.14 nM), whereas the R-amlodipine camsylate has 590-fold lower vasorelaxant activity (ED50: 886.4 ± 49.7 nM). In SHR, orally administered S-amlodipine camsylate produced a dose-dependent and long-lasting (>10 h) antihypertensive effect (ED20: 0.89 mg/kg), with a potency 2-fold higher than those of R/S-amlodipine camsylate (ED20: 1.82 mg/kg) and similar to those of S-amlodipine besylate (ED20: 0.71 mg/kg). In contrast, the R-amlodipine camsylate has no effect even-though administrated high concentration 10 mg/kg. These results suggest that S-amlodipine camsylate has the potency and long-lasting antihypertensive activity as single enantiomer drug, and its antihypertensive effect is not significantly different to that of S-amlodipine besylate." @default.
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- W2017112044 date "2007-03-30" @default.
- W2017112044 modified "2023-10-18" @default.
- W2017112044 title "Antihypertensive Effects of Enantiomers of Amlodipine Camsylate, a Novel Salt of Amlodipine" @default.
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- W2017112044 doi "https://doi.org/10.4062/biomolther.2007.15.1.040" @default.
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