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- W2017113713 abstract "The specific binding of aminoglycoside antibiotics to the bacterial ribosomal decoding site (A-site) has inspired the study of RNA–small molecules interactions and the search for novel RNA binders. Among the numerous RNA targets studied so far, the A-site holds a unique place. It is among the few truly validated RNA targets for which naturally occurring ligands have been discovered as “cognate” binders. In addition, due to its encapsulating architecture, the A-site is a more discriminating RNA target when compared to other RNA sequences. Previous observations and current challenges for the designers of potent and specific RNA binders are discussed." @default.
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- W2017113713 date "2006-08-01" @default.
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- W2017113713 title "The ribosomal A-site as an inspiration for the design of RNA binders" @default.
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- W2017113713 doi "https://doi.org/10.1016/j.biochi.2006.03.005" @default.
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