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- W2017115004 abstract "Over the past two decades, progress in the treatment of patients with metastatic squamous non-small-cell lung cancer has been limited. The EGFR is involved in tumor progression and invasion and therefore it has become the target of several studies in lung cancer. Strategies to block this pathway are focused on the development of small molecule (tyrosine kinase inhibitor) and monoclonal antibodies (mAbs). Some mAbs have been studied in patients with advanced non-small-cell lung cancer. For the first time, a fully human immunoglobulin G (IMC-11F8), subclass 1 (IgG1) mAb targeting the EGFR, in combination with standard chemotherapy (cisplatin + gemcitabine), has been shown to increase overall survival in chemo-naïve patients with metastatic confirmed squamous cell histology." @default.
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- W2017115004 date "2015-03-22" @default.
- W2017115004 modified "2023-09-24" @default.
- W2017115004 title "Necitumumab for the treatment of stage IV metastatic squamous non-small-cell lung cancer" @default.
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- W2017115004 doi "https://doi.org/10.1586/17476348.2015.1027688" @default.
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