FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2017119611> ?p ?o ?g. }

• W2017119611 endingPage "1175" @default.
• W2017119611 startingPage "1170" @default.
• W2017119611 abstract "Squamous dysplasia of the oral cavity indicates increased risk of progression to squamous cell carcinoma (SCC). An important advance would be the development of a minimally invasive assay for identification of oral SCC and dysplasia. We have investigated the suitability in this context of immunostaining oral smears for minichromosome maintainance proteins (MCMs), sensitive and specific biomarkers of cell cycle entry. Immunohistochemical examination of 66 oral tissue samples showed a greater frequency of Mcm-2 expression in surface layers of moderate/severe dysplasia and SCC compared to benign keratosis/mild dysplasia. Immunocytochemistry for Mcm-2/Mcm-5 was performed on 101 oral smears. Conventional smears included 23 from normal mucosa, benign proliferative disease and mild dysplasia, all of which were MCM negative. Of 52 conventional smears of SCC tissue samples, 18 were inadequate. However, MCM-positive cells were present in 33/34 adequate samples. Of 26 liquid-based cytology smears, 19 out of 20 smears from SCC were adequate and all were MCM positive. Six smears from benign lesions were adequate and MCM negative. We conclude that MCMs are promising markers for early detection of oral SCC and dysplasia, particularly in a liquid-based cytology platform. Detection of MCMs would be amenable to automation and potentially applicable in the developing world. Further studies are now warranted." @default.
• W2017119611 created "2016-06-24" @default.
• W2017119611 creator A5004342980 @default.
• W2017119611 creator A5010573501 @default.
• W2017119611 creator A5023965559 @default.
• W2017119611 creator A5051562152 @default.
• W2017119611 creator A5052810177 @default.
• W2017119611 creator A5066390499 @default.
• W2017119611 creator A5067577559 @default.
• W2017119611 creator A5071697406 @default.
• W2017119611 date "2006-04-01" @default.
• W2017119611 modified "2023-10-13" @default.
• W2017119611 title "A minimally invasive immunocytochemical approach to early detection of oral squamous cell carcinoma and dysplasia" @default.
• W2017119611 cites W1985934339 @default.
• W2017119611 cites W1987593383 @default.
• W2017119611 cites W1999384729 @default.
• W2017119611 cites W2014224087 @default.
• W2017119611 cites W2027666622 @default.
• W2017119611 cites W2032141702 @default.
• W2017119611 cites W2037602734 @default.
• W2017119611 cites W2052292487 @default.
• W2017119611 cites W2059504781 @default.
• W2017119611 cites W2065971145 @default.
• W2017119611 cites W2070315971 @default.
• W2017119611 cites W2124710135 @default.
• W2017119611 cites W2406213538 @default.
• W2017119611 cites W334093512 @default.
• W2017119611 doi "https://doi.org/10.1038/sj.bjc.6603066" @default.
• W2017119611 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2361243" @default.
• W2017119611 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16622441" @default.
• W2017119611 hasPublicationYear "2006" @default.
• W2017119611 type Work @default.
• W2017119611 sameAs 2017119611 @default.
• W2017119611 citedByCount "57" @default.
• W2017119611 countsByYear W20171196112012 @default.
• W2017119611 countsByYear W20171196112013 @default.
• W2017119611 countsByYear W20171196112014 @default.
• W2017119611 countsByYear W20171196112015 @default.
• W2017119611 countsByYear W20171196112016 @default.
• W2017119611 countsByYear W20171196112017 @default.
• W2017119611 countsByYear W20171196112018 @default.
• W2017119611 countsByYear W20171196112019 @default.
• W2017119611 countsByYear W20171196112020 @default.
• W2017119611 countsByYear W20171196112021 @default.
• W2017119611 countsByYear W20171196112022 @default.
• W2017119611 countsByYear W20171196112023 @default.
• W2017119611 crossrefType "journal-article" @default.
• W2017119611 hasAuthorship W2017119611A5004342980 @default.
• W2017119611 hasAuthorship W2017119611A5010573501 @default.
• W2017119611 hasAuthorship W2017119611A5023965559 @default.
• W2017119611 hasAuthorship W2017119611A5051562152 @default.
• W2017119611 hasAuthorship W2017119611A5052810177 @default.
• W2017119611 hasAuthorship W2017119611A5066390499 @default.
• W2017119611 hasAuthorship W2017119611A5067577559 @default.
• W2017119611 hasAuthorship W2017119611A5071697406 @default.
• W2017119611 hasBestOaLocation W20171196111 @default.
• W2017119611 hasConcept C142724271 @default.
• W2017119611 hasConcept C151730666 @default.
• W2017119611 hasConcept C204232928 @default.
• W2017119611 hasConcept C2775894508 @default.
• W2017119611 hasConcept C2777546739 @default.
• W2017119611 hasConcept C2777661416 @default.
• W2017119611 hasConcept C2779012181 @default.
• W2017119611 hasConcept C2779343474 @default.
• W2017119611 hasConcept C4224716 @default.
• W2017119611 hasConcept C71924100 @default.
• W2017119611 hasConcept C86803240 @default.
• W2017119611 hasConceptScore W2017119611C142724271 @default.
• W2017119611 hasConceptScore W2017119611C151730666 @default.
• W2017119611 hasConceptScore W2017119611C204232928 @default.
• W2017119611 hasConceptScore W2017119611C2775894508 @default.
• W2017119611 hasConceptScore W2017119611C2777546739 @default.
• W2017119611 hasConceptScore W2017119611C2777661416 @default.
• W2017119611 hasConceptScore W2017119611C2779012181 @default.
• W2017119611 hasConceptScore W2017119611C2779343474 @default.
• W2017119611 hasConceptScore W2017119611C4224716 @default.
• W2017119611 hasConceptScore W2017119611C71924100 @default.
• W2017119611 hasConceptScore W2017119611C86803240 @default.
• W2017119611 hasIssue "8" @default.
• W2017119611 hasLocation W20171196111 @default.
• W2017119611 hasLocation W20171196112 @default.
• W2017119611 hasLocation W20171196113 @default.
• W2017119611 hasLocation W20171196114 @default.
• W2017119611 hasOpenAccess W2017119611 @default.
• W2017119611 hasPrimaryLocation W20171196111 @default.
• W2017119611 hasRelatedWork W110523806 @default.
• W2017119611 hasRelatedWork W1546067550 @default.
• W2017119611 hasRelatedWork W1979893467 @default.
• W2017119611 hasRelatedWork W2313367396 @default.
• W2017119611 hasRelatedWork W2347823473 @default.
• W2017119611 hasRelatedWork W2512703498 @default.
• W2017119611 hasRelatedWork W2795936433 @default.
• W2017119611 hasRelatedWork W3035829157 @default.
• W2017119611 hasRelatedWork W4372141623 @default.
• W2017119611 hasRelatedWork W178124586 @default.
• W2017119611 hasVolume "94" @default.
• W2017119611 isParatext "false" @default.
• W2017119611 isRetracted "false" @default.

• next