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• W2017119797 abstract "Abstract Deletion of fibronectin or its receptor, α 5 integrin, interferes with the formation of a functional circulation in mice. We hypothesized that α 5 β 1 integrin/fibronectin interaction may be involved in differentiation of endothelial cells during angiogenesis. We examined the effect of blocking antibody against α 5 β 1 integrin in fibroblast growth factor‐2 (FGF‐2)‐induced angiogenesis by Matrigel plug assay. Although the antibody did not inhibit the recruitment of endothelial cells into plugs, it inhibited organization of lumen‐containing capillaries. The antibody also inhibited FGF‐2‐induced tube formation by murine brain capillary endothelial cells (IBE cells) cultured in type I collagen gels. We previously showed that FGF‐2 failed to induce tube formation by IBE cells expressing kinase‐dead c‐Fyn (KDFyn cells). Association with β‐catenin enhances the transcriptional activity of T‐cell factor‐4 (TCF‐4), which up‐regulates the expression of fibronectin. FGF‐2 induced association of β‐catenin with TCF‐4 and up‐regulation of fibronectin in IBE cells, but not in KDFyn cells. Expression of mutant TCF‐4, which does not associate with β‐catenin, inhibited FGF‐2‐induced tube formation and expression of fibronectin in IBE cells. FGF‐2‐induced tyrosine phosphorylation of β‐catenin, and association with TCF‐4 was increased in IBE cells, but not in KDFyn cells. Taken together, interaction of α 5 β 1 integrin and fibronectin is involved in FGF‐2‐induced tube formation by endothelial cells and up‐regulation of fibronectin through TCF‐4 seemed to be involved in this process. © 2004 Wiley‐Liss, Inc." @default.
• W2017119797 created "2016-06-24" @default.
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• W2017119797 date "2004-12-02" @default.
• W2017119797 modified "2023-10-13" @default.
• W2017119797 title "T-cell factor-4-dependent up-regulation of fibronectin is involved in fibroblast growth factor-2-induced tube formation by endothelial cells" @default.
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• W2017119797 doi "https://doi.org/10.1002/jcb.20354" @default.
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