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- W2017125120 abstract "Rats were tested for changes in shock-induced fighting following treatment with antidepressants of both the dibenzazepine and monoamine oxidase inhibitor classes of drug. Rats were retested for shock-induced fighting 3, 4, and 5 days after initial injections of imipramine (10 mg/kg IP bid), amitriptyline (10 mg/kg IP bid), and desmethylimipramine (10 mg/kg IP bid), or saline. All three dibenzazepine groups showed increased levels of shock-induced fighting (p<0.01). In addition, rats were retested for shock-induced fighting 6, 30, 54, and 78 hours following the initiation of treatment with daily injections of saline, or the monoamine oxidase inhibitors: nialamide (100 mg/kg/day), iproniazid (150 mg/kg/day), and pargyline (20 mg/kg/day). All three monoamine oxidase inhibitor groups showed increased levels of shock-induced fighting after 30 hr (p<0.001). There was no difference in the jump threshold of rats treated with pargyline or saline." @default.
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- W2017125120 title "Facilitated shock-induced aggression following antidepressive medication in the rat" @default.
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