FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2017128657> ?p ?o ?g. }

• W2017128657 endingPage "2490" @default.
• W2017128657 startingPage "2481" @default.
• W2017128657 abstract "MicroRNAs (MiRNAs) are small non-coding RNA molecules which act as important regulators of post-transcriptional gene expression by binding 3′-untranslated region (3′-UTR) of target messenger RNA (mRNA). In this study, we analyzed miRNA-34a (miR-34a) as a tumor suppressor in non-small cell lung cancer (NSCLC) H1299 cell line. The expression level of miR-34a in four different NSCLC cell lines, H1299, A549, SPCA-1, and HCC827, was significantly lower than that in the non-tumorigenic bronchial epithelium cell line BEAS-2B. In human NSCLC tissues, miR-34a expression level was also significantly decreased in pT2-4 compared with the pT1 group. Moreover, miR-34a mimic could inhibit the proliferation and triggered apoptosis in H1299 cells. Luciferase assays revealed that miR-34a inhibited TGFβR2 expression by targeting one binding site in the 3′-UTR of TGFβR2 mRNA. Quantitative real-time PCR (qRT-PCR) and Western blot assays verified that miR-34a reduced TGFβR2 expression at both mRNA and protein levels. Furthermore, downregulation of TGFβR2 by siRNA showed the same effects on the proliferation and apoptosis as miR-34a mimic in H1299 cells. Our results demonstrated that miR-34a could inhibit the proliferation and promote the apoptosis of H1299 cells partially through the downregulation of its target gene TGFβR2." @default.
• W2017128657 created "2016-06-24" @default.
• W2017128657 creator A5014167486 @default.
• W2017128657 creator A5020119849 @default.
• W2017128657 creator A5029298734 @default.
• W2017128657 creator A5032263180 @default.
• W2017128657 creator A5036015998 @default.
• W2017128657 creator A5057398876 @default.
• W2017128657 creator A5071420879 @default.
• W2017128657 creator A5076721028 @default.
• W2017128657 creator A5079548700 @default.
• W2017128657 creator A5080600358 @default.
• W2017128657 creator A5088684298 @default.
• W2017128657 date "2014-12-13" @default.
• W2017128657 modified "2023-10-01" @default.
• W2017128657 title "MicroRNA-34a inhibits the proliferation and promotes the apoptosis of non-small cell lung cancer H1299 cell line by targeting TGFβR2" @default.
• W2017128657 cites W1565561072 @default.
• W2017128657 cites W1968008181 @default.
• W2017128657 cites W1973081197 @default.
• W2017128657 cites W1985121353 @default.
• W2017128657 cites W1992638032 @default.
• W2017128657 cites W2000761432 @default.
• W2017128657 cites W2001134763 @default.
• W2017128657 cites W2022322735 @default.
• W2017128657 cites W2028169705 @default.
• W2017128657 cites W2031350461 @default.
• W2017128657 cites W2031475327 @default.
• W2017128657 cites W2033320521 @default.
• W2017128657 cites W2037066847 @default.
• W2017128657 cites W2038167014 @default.
• W2017128657 cites W2040587084 @default.
• W2017128657 cites W2047356483 @default.
• W2017128657 cites W2059160575 @default.
• W2017128657 cites W2059848983 @default.
• W2017128657 cites W2060080575 @default.
• W2017128657 cites W2070602415 @default.
• W2017128657 cites W2076062398 @default.
• W2017128657 cites W2083158631 @default.
• W2017128657 cites W2093364931 @default.
• W2017128657 cites W2094258666 @default.
• W2017128657 cites W2094375196 @default.
• W2017128657 cites W2094824446 @default.
• W2017128657 cites W2099758265 @default.
• W2017128657 cites W2106787323 @default.
• W2017128657 cites W2111655556 @default.
• W2017128657 cites W2116745900 @default.
• W2017128657 cites W2118773986 @default.
• W2017128657 cites W2123827665 @default.
• W2017128657 cites W2126059322 @default.
• W2017128657 cites W2134701923 @default.
• W2017128657 cites W2134823582 @default.
• W2017128657 cites W2136280424 @default.
• W2017128657 cites W2138343959 @default.
• W2017128657 cites W2142957616 @default.
• W2017128657 cites W2144154026 @default.
• W2017128657 cites W2149301055 @default.
• W2017128657 cites W2150536104 @default.
• W2017128657 cites W2166636120 @default.
• W2017128657 cites W2401044546 @default.
• W2017128657 cites W55127565 @default.
• W2017128657 doi "https://doi.org/10.1007/s13277-014-2861-5" @default.
• W2017128657 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25501507" @default.
• W2017128657 hasPublicationYear "2014" @default.
• W2017128657 type Work @default.
• W2017128657 sameAs 2017128657 @default.
• W2017128657 citedByCount "68" @default.
• W2017128657 countsByYear W20171286572015 @default.
• W2017128657 countsByYear W20171286572016 @default.
• W2017128657 countsByYear W20171286572017 @default.
• W2017128657 countsByYear W20171286572018 @default.
• W2017128657 countsByYear W20171286572019 @default.
• W2017128657 countsByYear W20171286572020 @default.
• W2017128657 countsByYear W20171286572021 @default.
• W2017128657 countsByYear W20171286572022 @default.
• W2017128657 countsByYear W20171286572023 @default.
• W2017128657 crossrefType "journal-article" @default.
• W2017128657 hasAuthorship W2017128657A5014167486 @default.
• W2017128657 hasAuthorship W2017128657A5020119849 @default.
• W2017128657 hasAuthorship W2017128657A5029298734 @default.
• W2017128657 hasAuthorship W2017128657A5032263180 @default.
• W2017128657 hasAuthorship W2017128657A5036015998 @default.
• W2017128657 hasAuthorship W2017128657A5057398876 @default.
• W2017128657 hasAuthorship W2017128657A5071420879 @default.
• W2017128657 hasAuthorship W2017128657A5076721028 @default.
• W2017128657 hasAuthorship W2017128657A5079548700 @default.
• W2017128657 hasAuthorship W2017128657A5080600358 @default.
• W2017128657 hasAuthorship W2017128657A5088684298 @default.
• W2017128657 hasConcept C104317684 @default.
• W2017128657 hasConcept C105580179 @default.
• W2017128657 hasConcept C118131993 @default.
• W2017128657 hasConcept C127561419 @default.
• W2017128657 hasConcept C145059251 @default.
• W2017128657 hasConcept C153911025 @default.
• W2017128657 hasConcept C185592680 @default.
• W2017128657 hasConcept C190283241 @default.
• W2017128657 hasConcept C502942594 @default.
• W2017128657 hasConcept C54355233 @default.
• W2017128657 hasConcept C55493867 @default.

• next