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- W2017129666 abstract "The neuronal cell line PC12 undergoes a well-documented morphological and biochemical differentiation when treated with NGF and other growth factors. A hallmark of this growth factor-mediated differentiation is the induction of the growth-associated protein, GAP43. Here we show that a PC12 cell line which is capable of NGF-, bFGF-, and cAMP-mediated neurite outgrowth is deficient in GAP-43 protein and full-length mRNA, as measured by immunocytochemistry, Western blot, Northern blot, and PCR analyses, respectively. We propose that the GAP-43 protein may not be essential for the initial extension and maintenance of neurites induced by these neuritogenic factors; rather, its role may lie predominantly in growth cone function and in the operation of the presynaptic terminal." @default.
- W2017129666 created "2016-06-24" @default.
- W2017129666 creator A5050667995 @default.
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- W2017129666 date "1991-01-01" @default.
- W2017129666 modified "2023-10-11" @default.
- W2017129666 title "Neurite outgrowth in PC12 cells deficient in GAP-43" @default.
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- W2017129666 doi "https://doi.org/10.1016/0896-6273(91)90118-j" @default.
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