Matches in SemOpenAlex for { <https://semopenalex.org/work/W2017130430> ?p ?o ?g. }
- W2017130430 endingPage "1590" @default.
- W2017130430 startingPage "1585" @default.
- W2017130430 abstract "Peroxisome proliferator-activated receptors (PPARs) are ligand-dependent transcription factors, and it is assumed that the biological effects of these receptors depend on interactions with recently identified coactivators, including steroid receptor coactivator-1 (SRC-1). We assessed the in vivo function of SRC-1 on the PPARalpha-regulated gene expression in liver by generating mice in which the SRC-1 gene was inactivated by gene targeting. The homozygous (SRC-1(-/-)) mice were viable and fertile and exhibited no detectable gross phenotypic defects. When challenged with a PPARalpha ligand, such as ciprofibrate or Wy-14,643, the SRC-1(-/-) mice displayed typical pleiotropic responses, including hepatomegaly, peroxisome proliferation in hepatocytes, and increased mRNA and protein levels of genes that are regulated by PPARalpha. These alterations were indistinguishable from those exhibited by SRC-1(+/+) wild-type mice fed either ciprofibrate- or Wy-14, 643-containing diets. These results indicate that SRC-1 is not essential for PPARalpha-mediated transcriptional activation in vivo and suggest redundancy in nuclear receptor coactivators." @default.
- W2017130430 created "2016-06-24" @default.
- W2017130430 creator A5028260860 @default.
- W2017130430 creator A5031112487 @default.
- W2017130430 creator A5034754078 @default.
- W2017130430 creator A5046172306 @default.
- W2017130430 creator A5061442073 @default.
- W2017130430 creator A5064538645 @default.
- W2017130430 creator A5064692183 @default.
- W2017130430 creator A5076453661 @default.
- W2017130430 creator A5084472017 @default.
- W2017130430 creator A5091708188 @default.
- W2017130430 date "1999-02-16" @default.
- W2017130430 modified "2023-09-23" @default.
- W2017130430 title "Mouse steroid receptor coactivator-1 is not essential for peroxisome proliferator-activated receptor α-regulated gene expression" @default.
- W2017130430 cites W1493268813 @default.
- W2017130430 cites W1501286679 @default.
- W2017130430 cites W1559792721 @default.
- W2017130430 cites W1596796792 @default.
- W2017130430 cites W1613446635 @default.
- W2017130430 cites W1646199134 @default.
- W2017130430 cites W1971432398 @default.
- W2017130430 cites W1974127600 @default.
- W2017130430 cites W1976976178 @default.
- W2017130430 cites W1979761686 @default.
- W2017130430 cites W1981022538 @default.
- W2017130430 cites W1981946836 @default.
- W2017130430 cites W1985063313 @default.
- W2017130430 cites W1986163599 @default.
- W2017130430 cites W1991996819 @default.
- W2017130430 cites W2001177059 @default.
- W2017130430 cites W2002799953 @default.
- W2017130430 cites W2008557193 @default.
- W2017130430 cites W2008632158 @default.
- W2017130430 cites W2009269691 @default.
- W2017130430 cites W2012155675 @default.
- W2017130430 cites W2017153232 @default.
- W2017130430 cites W2022110250 @default.
- W2017130430 cites W2047982128 @default.
- W2017130430 cites W2060128629 @default.
- W2017130430 cites W2066092624 @default.
- W2017130430 cites W2067421512 @default.
- W2017130430 cites W2068113812 @default.
- W2017130430 cites W2073133361 @default.
- W2017130430 cites W2085792867 @default.
- W2017130430 cites W2085867188 @default.
- W2017130430 cites W2088534912 @default.
- W2017130430 cites W2090553336 @default.
- W2017130430 cites W2090939833 @default.
- W2017130430 cites W2094558395 @default.
- W2017130430 cites W2102106861 @default.
- W2017130430 cites W2113456624 @default.
- W2017130430 cites W2121914083 @default.
- W2017130430 cites W2123116985 @default.
- W2017130430 cites W2123898551 @default.
- W2017130430 cites W2143241514 @default.
- W2017130430 cites W2158268923 @default.
- W2017130430 cites W2164015929 @default.
- W2017130430 cites W2172256092 @default.
- W2017130430 cites W2428337977 @default.
- W2017130430 doi "https://doi.org/10.1073/pnas.96.4.1585" @default.
- W2017130430 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/15526" @default.
- W2017130430 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9990068" @default.
- W2017130430 hasPublicationYear "1999" @default.
- W2017130430 type Work @default.
- W2017130430 sameAs 2017130430 @default.
- W2017130430 citedByCount "72" @default.
- W2017130430 countsByYear W20171304302012 @default.
- W2017130430 countsByYear W20171304302013 @default.
- W2017130430 countsByYear W20171304302014 @default.
- W2017130430 countsByYear W20171304302015 @default.
- W2017130430 countsByYear W20171304302016 @default.
- W2017130430 countsByYear W20171304302018 @default.
- W2017130430 countsByYear W20171304302019 @default.
- W2017130430 crossrefType "journal-article" @default.
- W2017130430 hasAuthorship W2017130430A5028260860 @default.
- W2017130430 hasAuthorship W2017130430A5031112487 @default.
- W2017130430 hasAuthorship W2017130430A5034754078 @default.
- W2017130430 hasAuthorship W2017130430A5046172306 @default.
- W2017130430 hasAuthorship W2017130430A5061442073 @default.
- W2017130430 hasAuthorship W2017130430A5064538645 @default.
- W2017130430 hasAuthorship W2017130430A5064692183 @default.
- W2017130430 hasAuthorship W2017130430A5076453661 @default.
- W2017130430 hasAuthorship W2017130430A5084472017 @default.
- W2017130430 hasAuthorship W2017130430A5091708188 @default.
- W2017130430 hasBestOaLocation W20171304301 @default.
- W2017130430 hasConcept C104317684 @default.
- W2017130430 hasConcept C108636557 @default.
- W2017130430 hasConcept C124170894 @default.
- W2017130430 hasConcept C126322002 @default.
- W2017130430 hasConcept C134018914 @default.
- W2017130430 hasConcept C170493617 @default.
- W2017130430 hasConcept C187345961 @default.
- W2017130430 hasConcept C188413054 @default.
- W2017130430 hasConcept C195598365 @default.
- W2017130430 hasConcept C203966977 @default.
- W2017130430 hasConcept C55493867 @default.
- W2017130430 hasConcept C63932345 @default.