FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2017131853> ?p ?o ?g. }

• W2017131853 endingPage "587" @default.
• W2017131853 startingPage "580" @default.
• W2017131853 abstract "Both alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) receptor-mediated neurotoxicity and the induction of death-regulatory genes have been implicated in the pathophysiology of delayed ischemic neuronal injury. To assess the role of the antiapoptotic gene Bcl-2 in the modulation of AMPA toxicity, we exposed neuron-enriched cultures from rat cerebral cortex to AMPA, in the absence or presence of an antisense oligodeoxynucleotide (ODN) directed against Bcl-2. AMPA produced concentration-dependent toxicity detected by a decrease in fluorescence of the redox indicator Alamar blue and by an increase in lactic acid dehydrogenase release. This effect was accompanied by the induction of Bcl-2 protein expression, with maximal induction at 100 microM AMPA. A phosphorothioate antisense ODN against Bcl-2 reduced the AMPA-stimulated induction of Bcl-2 protein levels, detected by western blotting, by about 70%. In the presence of the antisense ODN, but not sense or scrambled ODNs, the toxicity of 100 microM AMPA was increased by about 60%. These findings suggest that induction of Bcl-2 expression by AMPA may have a protective role to limit AMPA receptor-mediated neuronal damage and that modifying Bcl-2 expression could have therapeutic potential in ischemia." @default.
• W2017131853 created "2016-06-24" @default.
• W2017131853 creator A5005674089 @default.
• W2017131853 creator A5020577454 @default.
• W2017131853 creator A5022331428 @default.
• W2017131853 creator A5056477026 @default.
• W2017131853 creator A5056781435 @default.
• W2017131853 creator A5073729732 @default.
• W2017131853 creator A5080176407 @default.
• W2017131853 creator A5082857859 @default.
• W2017131853 date "1997-10-01" @default.
• W2017131853 modified "2023-09-26" @default.
• W2017131853 title "A Bcl-2 antisense oligonucleotide increases ?-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) toxicity in cortical cultures" @default.
• W2017131853 cites W1529927626 @default.
• W2017131853 cites W1549546756 @default.
• W2017131853 cites W1584607831 @default.
• W2017131853 cites W1648092162 @default.
• W2017131853 cites W1970257143 @default.
• W2017131853 cites W1975896299 @default.
• W2017131853 cites W1980762080 @default.
• W2017131853 cites W1983112915 @default.
• W2017131853 cites W1983913371 @default.
• W2017131853 cites W1983931044 @default.
• W2017131853 cites W1984374912 @default.
• W2017131853 cites W1996708582 @default.
• W2017131853 cites W2000304313 @default.
• W2017131853 cites W2006239014 @default.
• W2017131853 cites W2009339203 @default.
• W2017131853 cites W2013019942 @default.
• W2017131853 cites W2019572526 @default.
• W2017131853 cites W2022973264 @default.
• W2017131853 cites W2025601212 @default.
• W2017131853 cites W2031102482 @default.
• W2017131853 cites W2033828028 @default.
• W2017131853 cites W2035750459 @default.
• W2017131853 cites W2037473273 @default.
• W2017131853 cites W2038813809 @default.
• W2017131853 cites W2040332557 @default.
• W2017131853 cites W2045949644 @default.
• W2017131853 cites W2057638542 @default.
• W2017131853 cites W2059006262 @default.
• W2017131853 cites W2063685774 @default.
• W2017131853 cites W2064075957 @default.
• W2017131853 cites W2066168019 @default.
• W2017131853 cites W2067334833 @default.
• W2017131853 cites W2080370764 @default.
• W2017131853 cites W2091599040 @default.
• W2017131853 cites W2095358033 @default.
• W2017131853 cites W2117477385 @default.
• W2017131853 cites W2144074374 @default.
• W2017131853 cites W2164169192 @default.
• W2017131853 cites W2182825613 @default.
• W2017131853 cites W4211045864 @default.
• W2017131853 doi "https://doi.org/10.1002/ana.410420408" @default.
• W2017131853 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9382469" @default.
• W2017131853 hasPublicationYear "1997" @default.
• W2017131853 type Work @default.
• W2017131853 sameAs 2017131853 @default.
• W2017131853 citedByCount "5" @default.
• W2017131853 crossrefType "journal-article" @default.
• W2017131853 hasAuthorship W2017131853A5005674089 @default.
• W2017131853 hasAuthorship W2017131853A5020577454 @default.
• W2017131853 hasAuthorship W2017131853A5022331428 @default.
• W2017131853 hasAuthorship W2017131853A5056477026 @default.
• W2017131853 hasAuthorship W2017131853A5056781435 @default.
• W2017131853 hasAuthorship W2017131853A5073729732 @default.
• W2017131853 hasAuthorship W2017131853A5080176407 @default.
• W2017131853 hasAuthorship W2017131853A5082857859 @default.
• W2017131853 hasConcept C153911025 @default.
• W2017131853 hasConcept C160268369 @default.
• W2017131853 hasConcept C170493617 @default.
• W2017131853 hasConcept C178790620 @default.
• W2017131853 hasConcept C185592680 @default.
• W2017131853 hasConcept C2779491297 @default.
• W2017131853 hasConcept C29730261 @default.
• W2017131853 hasConcept C55493867 @default.
• W2017131853 hasConcept C61174792 @default.
• W2017131853 hasConcept C86803240 @default.
• W2017131853 hasConcept C98274493 @default.
• W2017131853 hasConceptScore W2017131853C153911025 @default.
• W2017131853 hasConceptScore W2017131853C160268369 @default.
• W2017131853 hasConceptScore W2017131853C170493617 @default.
• W2017131853 hasConceptScore W2017131853C178790620 @default.
• W2017131853 hasConceptScore W2017131853C185592680 @default.
• W2017131853 hasConceptScore W2017131853C2779491297 @default.
• W2017131853 hasConceptScore W2017131853C29730261 @default.
• W2017131853 hasConceptScore W2017131853C55493867 @default.
• W2017131853 hasConceptScore W2017131853C61174792 @default.
• W2017131853 hasConceptScore W2017131853C86803240 @default.
• W2017131853 hasConceptScore W2017131853C98274493 @default.
• W2017131853 hasIssue "4" @default.
• W2017131853 hasLocation W20171318531 @default.
• W2017131853 hasLocation W20171318532 @default.
• W2017131853 hasOpenAccess W2017131853 @default.
• W2017131853 hasPrimaryLocation W20171318531 @default.
• W2017131853 hasRelatedWork W1904529830 @default.
• W2017131853 hasRelatedWork W1980412511 @default.
• W2017131853 hasRelatedWork W1989684741 @default.

• next