FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2017134617> ?p ?o ?g. }

• W2017134617 endingPage "1023" @default.
• W2017134617 startingPage "1011" @default.
• W2017134617 abstract "DNA interstrand cross-links (ICLs) represent a physical barrier to the progression of cellular machinery involved in DNA metabolism. Thus, this type of adduct represents a serious threat to genomic stability and as such, several DNA repair pathways have evolved in both higher and lower eukaryotes to identify this type of damage and restore the integrity of the genetic material. Human cells possess a specialized ICL-repair system, the Fanconi anemia (FA) pathway. Conversely yeasts rely on the concerted action of several DNA repair systems. Recent work in higher eukaryotes identified and characterized a novel conserved FA component, FAN1 (Fanconi anemia-associated nuclease 1, or FANCD2/FANCI-associated nuclease 1). In this study, we characterize Fan1 in the yeast Schizosaccharomyces pombe. Using standard genetics, we demonstrate that Fan1 is a key component of a previously unidentified ICL-resolution pathway. Using high-throughput synthetic genetic arrays, we also demonstrate the existence of a third pathway of ICL repair, dependent on the SUMO E3 ligase Pli1. Finally, using sequence-threaded homology models, we predict and validate key residues essential for Fan1 activity in ICL repair." @default.
• W2017134617 created "2016-06-24" @default.
• W2017134617 creator A5011271805 @default.
• W2017134617 creator A5022756497 @default.
• W2017134617 creator A5037995291 @default.
• W2017134617 creator A5043678085 @default.
• W2017134617 creator A5072464988 @default.
• W2017134617 date "2013-12-01" @default.
• W2017134617 modified "2023-09-28" @default.
• W2017134617 title "The conserved Fanconi anemia nuclease Fan1 and the SUMO E3 ligase Pli1 act in two novel Pso2-independent pathways of DNA interstrand crosslink repair in yeast" @default.
• W2017134617 cites W1839681995 @default.
• W2017134617 cites W1902781624 @default.
• W2017134617 cites W1965324768 @default.
• W2017134617 cites W1965495050 @default.
• W2017134617 cites W1986533903 @default.
• W2017134617 cites W1987895683 @default.
• W2017134617 cites W1989643386 @default.
• W2017134617 cites W2009074048 @default.
• W2017134617 cites W2009430092 @default.
• W2017134617 cites W2019683899 @default.
• W2017134617 cites W2027970788 @default.
• W2017134617 cites W2028233890 @default.
• W2017134617 cites W2034016149 @default.
• W2017134617 cites W2034100797 @default.
• W2017134617 cites W2040795152 @default.
• W2017134617 cites W2042818609 @default.
• W2017134617 cites W2043923950 @default.
• W2017134617 cites W2049812251 @default.
• W2017134617 cites W2052521064 @default.
• W2017134617 cites W2076459721 @default.
• W2017134617 cites W2077504895 @default.
• W2017134617 cites W2078170397 @default.
• W2017134617 cites W2084624885 @default.
• W2017134617 cites W2086482792 @default.
• W2017134617 cites W2087967916 @default.
• W2017134617 cites W2096048754 @default.
• W2017134617 cites W2099392759 @default.
• W2017134617 cites W2100771513 @default.
• W2017134617 cites W2101794075 @default.
• W2017134617 cites W2109468970 @default.
• W2017134617 cites W2109482063 @default.
• W2017134617 cites W2114180794 @default.
• W2017134617 cites W2114776482 @default.
• W2017134617 cites W2117266220 @default.
• W2017134617 cites W2121150109 @default.
• W2017134617 cites W2129849452 @default.
• W2017134617 cites W2138425441 @default.
• W2017134617 cites W2139412905 @default.
• W2017134617 cites W2144175569 @default.
• W2017134617 cites W2144550200 @default.
• W2017134617 cites W2144628609 @default.
• W2017134617 cites W2150915103 @default.
• W2017134617 cites W2159859860 @default.
• W2017134617 cites W2159928328 @default.
• W2017134617 cites W2162385336 @default.
• W2017134617 cites W2163492475 @default.
• W2017134617 cites W2168946581 @default.
• W2017134617 doi "https://doi.org/10.1016/j.dnarep.2013.10.003" @default.
• W2017134617 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4045212" @default.
• W2017134617 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24192486" @default.
• W2017134617 hasPublicationYear "2013" @default.
• W2017134617 type Work @default.
• W2017134617 sameAs 2017134617 @default.
• W2017134617 citedByCount "20" @default.
• W2017134617 countsByYear W20171346172014 @default.
• W2017134617 countsByYear W20171346172015 @default.
• W2017134617 countsByYear W20171346172016 @default.
• W2017134617 countsByYear W20171346172017 @default.
• W2017134617 countsByYear W20171346172018 @default.
• W2017134617 countsByYear W20171346172019 @default.
• W2017134617 countsByYear W20171346172020 @default.
• W2017134617 countsByYear W20171346172021 @default.
• W2017134617 crossrefType "journal-article" @default.
• W2017134617 hasAuthorship W2017134617A5011271805 @default.
• W2017134617 hasAuthorship W2017134617A5022756497 @default.
• W2017134617 hasAuthorship W2017134617A5037995291 @default.
• W2017134617 hasAuthorship W2017134617A5043678085 @default.
• W2017134617 hasAuthorship W2017134617A5072464988 @default.
• W2017134617 hasBestOaLocation W20171346171 @default.
• W2017134617 hasConcept C134935766 @default.
• W2017134617 hasConcept C143425029 @default.
• W2017134617 hasConcept C175114707 @default.
• W2017134617 hasConcept C178169997 @default.
• W2017134617 hasConcept C2776519988 @default.
• W2017134617 hasConcept C2776653068 @default.
• W2017134617 hasConcept C2777271071 @default.
• W2017134617 hasConcept C2777576037 @default.
• W2017134617 hasConcept C2778124228 @default.
• W2017134617 hasConcept C2779222958 @default.
• W2017134617 hasConcept C2779429346 @default.
• W2017134617 hasConcept C54355233 @default.
• W2017134617 hasConcept C552990157 @default.
• W2017134617 hasConcept C86803240 @default.
• W2017134617 hasConcept C95444343 @default.
• W2017134617 hasConceptScore W2017134617C134935766 @default.
• W2017134617 hasConceptScore W2017134617C143425029 @default.
• W2017134617 hasConceptScore W2017134617C175114707 @default.
• W2017134617 hasConceptScore W2017134617C178169997 @default.

• next