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- W2017137212 abstract "The inhibiting action of prostaglandin E1 (PGE1) on platelet aggregation in circulating rat blood was studied quantitatively. PGE1, given intravascularly, produced very strong but short-lasting inhibition of ADP-induced platelet aggregation. When PGE1 was given in a mixture with ADP, the relation between log dose PGE1 (0.16–5.0 × 10−2 μg/30 sec) and aggregation inhibition was positive and rectilinear; the inhibiting action of all doses tested lasted less than 10 min. However, after subcutaneous, intramuscular or intraperitoneal (i.p.) injection of 50 μg PGE1, inhibition lasted 10–20, 30–40 and over 90 min, respectively. When 3.125, 6.25, 12.5 or 25 μg PGE1 was administered i.p., duration of the aggregation inhibiting action (AIA) was about 10, 10 60 or 70 min, respectively. Intraperitoneal administration of 12.5–50 μg PGE1 caused a biphasic AIA, possibly as a result of a PGE1-induced serotonin release. The results indicate that PGE1 is suitable for the prevention of intravascular thrombocyte aggregation and may be useful clinically." @default.
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- W2017137212 date "1971-08-01" @default.
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- W2017137212 title "Degree and duration of prostaglandin E1-induced inhibition of platelet aggregation in the rat" @default.
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- W2017137212 doi "https://doi.org/10.1016/0014-2999(71)90101-4" @default.
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