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• W2017139557 abstract "Protein kinase D (PKD)/protein kinase Cmicro (PKCmicro, a serine/threonine protein kinase with distinct structural and enzymological properties, is rapidly activated in intact cells via PKC. The amino-terminal region of PKD contains a cysteine-rich domain (CRD) that directly binds phorbol esters with a high affinity. Here, we show that treatment of transfected RBL 2H3 cells with phorbol 12,13-dibutyrate (PDB) induces a striking CRD-dependent translocation of PKD from the cytosol to the plasma membrane, as shown by real time visualization of a functional green fluorescent protein (GFP)-PKD fusion protein. A single amino acid substitution in the second cysteine-rich motif of PKD (P287G) prevented PDB-induced membrane translocation but did not affect PKD activation. Our results indicate that PKD translocation and activation are distinct processes that operate in parallel to regulate the activity and localization of this enzyme in intact cells." @default.
• W2017139557 created "2016-06-24" @default.
• W2017139557 creator A5019327627 @default.
• W2017139557 creator A5022919403 @default.
• W2017139557 creator A5051258037 @default.
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• W2017139557 date "1999-09-02" @default.
• W2017139557 modified "2023-10-16" @default.
• W2017139557 title "Dynamic re-distribution of protein kinase D (PKD) as revealed by a GFP-PKD fusion protein: dissociation from PKD activation" @default.
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• W2017139557 doi "https://doi.org/10.1016/s0014-5793(99)01090-x" @default.
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