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- W2017139710 abstract "Prolonged critical illness has high morbidity and mortality. The acute neuroendocrine response to critical illness involves an activated anterior pituitary function. In prolonged critical illness, however, a reduced pulsatile secretion of anterior pituitary hormones and the so-called 'wasting syndrome' occur. The impaired pulsatile secretion of growth hormone (GH), thyrotropin and gonadotropin can be re-amplified by relevant combinations of releasing factors, which also substantially increase circulating levels of insulin-like growth factor (IGF)-I, GH-dependent IGF-binding proteins, thyroxine, tri-iodothyronine, and testosterone. Anabolism is clearly re-initiated when GH secretagogues, thyrotropin-releasing and gonadotropin-releasing hormones are co-administered but the effect on survival remains unknown. A lethal outcome of critical illness is predicted by a high serum concentration of IGF-binding protein 1, pointing to impaired insulin effect rather than pituitary function, and survival was recently shown to be dramatically improved by strict normalization of glycemia with exogenous insulin. The recent progress in the knowledge of the neuroendocrine response to critical illness and its interrelation with peripheral hormonal and metabolic alterations during stress allows for potential new therapeutic perspectives to safely reverse the wasting syndrome and improve survival. These novel insights will be reviewed herein." @default.
- W2017139710 created "2016-06-24" @default.
- W2017139710 creator A5042145557 @default.
- W2017139710 date "2002-10-01" @default.
- W2017139710 modified "2023-10-12" @default.
- W2017139710 title "Dynamic neuroendocrine responses to critical illness" @default.
- W2017139710 cites W1583233550 @default.
- W2017139710 cites W1966768389 @default.
- W2017139710 cites W1968842325 @default.
- W2017139710 cites W1968992628 @default.
- W2017139710 cites W1969576589 @default.
- W2017139710 cites W1974069757 @default.
- W2017139710 cites W1975929235 @default.
- W2017139710 cites W1980356204 @default.
- W2017139710 cites W1980717583 @default.
- W2017139710 cites W1980941499 @default.
- W2017139710 cites W1982428806 @default.
- W2017139710 cites W1985625612 @default.
- W2017139710 cites W1992966972 @default.
- W2017139710 cites W1995684114 @default.
- W2017139710 cites W1995734405 @default.
- W2017139710 cites W2001131147 @default.
- W2017139710 cites W2004617421 @default.
- W2017139710 cites W2005111715 @default.
- W2017139710 cites W2007971998 @default.
- W2017139710 cites W2017515252 @default.
- W2017139710 cites W2019138828 @default.
- W2017139710 cites W2020116931 @default.
- W2017139710 cites W2020610635 @default.
- W2017139710 cites W2024048326 @default.
- W2017139710 cites W2029114578 @default.
- W2017139710 cites W2031879800 @default.
- W2017139710 cites W2033155942 @default.
- W2017139710 cites W2038496971 @default.
- W2017139710 cites W2038898831 @default.
- W2017139710 cites W2039380871 @default.
- W2017139710 cites W2042407186 @default.
- W2017139710 cites W2043794168 @default.
- W2017139710 cites W2045341167 @default.
- W2017139710 cites W2049747788 @default.
- W2017139710 cites W2050996454 @default.
- W2017139710 cites W2052598407 @default.
- W2017139710 cites W2058099637 @default.
- W2017139710 cites W2059156857 @default.
- W2017139710 cites W2062659760 @default.
- W2017139710 cites W2063463365 @default.
- W2017139710 cites W2063782997 @default.
- W2017139710 cites W2065755424 @default.
- W2017139710 cites W2067943766 @default.
- W2017139710 cites W2069571646 @default.
- W2017139710 cites W2070398372 @default.
- W2017139710 cites W2073399860 @default.
- W2017139710 cites W2075789987 @default.
- W2017139710 cites W2076620802 @default.
- W2017139710 cites W2077563872 @default.
- W2017139710 cites W2079821887 @default.
- W2017139710 cites W2080500635 @default.
- W2017139710 cites W2083323668 @default.
- W2017139710 cites W2087866877 @default.
- W2017139710 cites W2089471666 @default.
- W2017139710 cites W2089478895 @default.
- W2017139710 cites W2090789426 @default.
- W2017139710 cites W2090798099 @default.
- W2017139710 cites W2093442315 @default.
- W2017139710 cites W2095029545 @default.
- W2017139710 cites W2097040314 @default.
- W2017139710 cites W2098580669 @default.
- W2017139710 cites W2106291421 @default.
- W2017139710 cites W2107062893 @default.
- W2017139710 cites W2116123122 @default.
- W2017139710 cites W2118450167 @default.
- W2017139710 cites W2154379123 @default.
- W2017139710 cites W2156297533 @default.
- W2017139710 cites W2157764912 @default.
- W2017139710 cites W2159281942 @default.
- W2017139710 cites W2163865122 @default.
- W2017139710 cites W2341722765 @default.
- W2017139710 cites W3144696145 @default.
- W2017139710 cites W4293242440 @default.
- W2017139710 cites W4376849282 @default.
- W2017139710 doi "https://doi.org/10.1016/s0091-3022(02)00006-7" @default.
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