Matches in SemOpenAlex for { <https://semopenalex.org/work/W2017140295> ?p ?o ?g. }
- W2017140295 endingPage "832" @default.
- W2017140295 startingPage "825" @default.
- W2017140295 abstract "Increased mitochondrial Ca2+ accumulation is a trigger for the release of cytochrome c from the mitochondrial intermembrane space into the cytosol where it can activate caspases and lead to apoptosis. This study tested the hypothesis that Ca2+-induced release of cytochrome c in vitro can occur by membrane permeability transition (MPT)-dependent and independent mechanisms, depending on the tissue from which mitochondria are isolated. Mitochondria were isolated from rat liver and brain and suspended at 37°C in a K+-based medium containing oxidizable substrates, ATP, and Mg2+. Measurements of changes in mitochondrial volume (via light scattering and electron microscopy), membrane potential and the medium free [Ca2+] indicated that the addition of 0.3–3.2 μmol Ca2+ mg−1 protein induced the MPT in liver but not brain mitochondria. Under these conditions, a Ca2+ dose-dependent release of cytochrome c was observed with both types of mitochondria; however, the MPT inhibitor cyclosporin A was only capable of inhibiting this release from liver mitochondria. Therefore, the MPT is responsible for cytochrome c release from liver mitochondria, whereas an MPT-independent mechanism is responsible for release from brain mitochondria." @default.
- W2017140295 created "2016-06-24" @default.
- W2017140295 creator A5033439967 @default.
- W2017140295 creator A5080399968 @default.
- W2017140295 date "1999-09-01" @default.
- W2017140295 modified "2023-10-07" @default.
- W2017140295 title "Calcium induced release of mitochondrial cytochrome c by different mechanisms selective for brain versus liver" @default.
- W2017140295 cites W1492823505 @default.
- W2017140295 cites W1507410890 @default.
- W2017140295 cites W1644794975 @default.
- W2017140295 cites W1876476959 @default.
- W2017140295 cites W1966448402 @default.
- W2017140295 cites W1966539065 @default.
- W2017140295 cites W1976226379 @default.
- W2017140295 cites W1979995768 @default.
- W2017140295 cites W1980969730 @default.
- W2017140295 cites W1985731963 @default.
- W2017140295 cites W1988355439 @default.
- W2017140295 cites W1995628673 @default.
- W2017140295 cites W1996568613 @default.
- W2017140295 cites W1996907401 @default.
- W2017140295 cites W2007294454 @default.
- W2017140295 cites W2017392776 @default.
- W2017140295 cites W2019403369 @default.
- W2017140295 cites W2021528199 @default.
- W2017140295 cites W2021678802 @default.
- W2017140295 cites W2029431403 @default.
- W2017140295 cites W2036599441 @default.
- W2017140295 cites W2050769762 @default.
- W2017140295 cites W2050994823 @default.
- W2017140295 cites W2051258629 @default.
- W2017140295 cites W2052793452 @default.
- W2017140295 cites W2053534803 @default.
- W2017140295 cites W2055094310 @default.
- W2017140295 cites W2063385957 @default.
- W2017140295 cites W2063772445 @default.
- W2017140295 cites W2064196264 @default.
- W2017140295 cites W2072858020 @default.
- W2017140295 cites W2074330066 @default.
- W2017140295 cites W2075477970 @default.
- W2017140295 cites W2076610743 @default.
- W2017140295 cites W2077529180 @default.
- W2017140295 cites W2092146469 @default.
- W2017140295 cites W2094247127 @default.
- W2017140295 cites W2094748455 @default.
- W2017140295 cites W2108131089 @default.
- W2017140295 cites W2110029891 @default.
- W2017140295 cites W2125562918 @default.
- W2017140295 cites W2130866079 @default.
- W2017140295 cites W2143302994 @default.
- W2017140295 cites W2146027360 @default.
- W2017140295 cites W2149687359 @default.
- W2017140295 cites W2151863888 @default.
- W2017140295 cites W2155747798 @default.
- W2017140295 cites W2168496647 @default.
- W2017140295 cites W2331647907 @default.
- W2017140295 doi "https://doi.org/10.1038/sj.cdd.4400565" @default.
- W2017140295 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10510464" @default.
- W2017140295 hasPublicationYear "1999" @default.
- W2017140295 type Work @default.
- W2017140295 sameAs 2017140295 @default.
- W2017140295 citedByCount "187" @default.
- W2017140295 countsByYear W20171402952012 @default.
- W2017140295 countsByYear W20171402952013 @default.
- W2017140295 countsByYear W20171402952014 @default.
- W2017140295 countsByYear W20171402952015 @default.
- W2017140295 countsByYear W20171402952017 @default.
- W2017140295 countsByYear W20171402952018 @default.
- W2017140295 countsByYear W20171402952019 @default.
- W2017140295 countsByYear W20171402952020 @default.
- W2017140295 countsByYear W20171402952021 @default.
- W2017140295 countsByYear W20171402952022 @default.
- W2017140295 countsByYear W20171402952023 @default.
- W2017140295 crossrefType "journal-article" @default.
- W2017140295 hasAuthorship W2017140295A5033439967 @default.
- W2017140295 hasAuthorship W2017140295A5080399968 @default.
- W2017140295 hasBestOaLocation W20171402951 @default.
- W2017140295 hasConcept C104317684 @default.
- W2017140295 hasConcept C12554922 @default.
- W2017140295 hasConcept C13591479 @default.
- W2017140295 hasConcept C146587185 @default.
- W2017140295 hasConcept C173358068 @default.
- W2017140295 hasConcept C178790620 @default.
- W2017140295 hasConcept C181199279 @default.
- W2017140295 hasConcept C181911157 @default.
- W2017140295 hasConcept C185592680 @default.
- W2017140295 hasConcept C186850619 @default.
- W2017140295 hasConcept C190283241 @default.
- W2017140295 hasConcept C193349765 @default.
- W2017140295 hasConcept C2780768313 @default.
- W2017140295 hasConcept C28859421 @default.
- W2017140295 hasConcept C29311851 @default.
- W2017140295 hasConcept C31573885 @default.
- W2017140295 hasConcept C519063684 @default.
- W2017140295 hasConcept C547475151 @default.
- W2017140295 hasConcept C55493867 @default.
- W2017140295 hasConcept C75385678 @default.
- W2017140295 hasConcept C86803240 @default.