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• W2017140462 abstract "In the present study, we examined the participation of CD40 ligand (L)-CD40 interaction in T cell-dependent B cell responses. To this end, purified B lymphocytes were cultured over irradiated CD4+ cloned T cells activated with immobilized anti-CD3 antibody. The anti-CD40 mAb 89 strongly blocked, in a specific fashion, both proliferation and Ig secretion of tonsil B cells. Interestingly, proliferation of surface (s)IgD+ B cell was significantly less inhibited by anti-CD40 than that of sIgD− cells. Preactivated T cells induced B cells to grow and secrete immunoglobulins preferentially in response to IL-2. This contrasts with the CD40 system where B cells are essentially responsive to IL-4 and IL-10 but not to IL-2 alone. Collectively, these data indicate that CD40L-CD40 interaction plays an important role in IL-2-mediated T cell-dependent B cell responses. However, the activation of a subset of sIgD+ cells may be independent of this interaction." @default.
• W2017140462 created "2016-06-24" @default.
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• W2017140462 date "1994-02-01" @default.
• W2017140462 modified "2023-09-25" @default.
• W2017140462 title "Role of CD40 antigen and interleukin-2 in T cell-dependent human B lymphocyte growth" @default.
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• W2017140462 doi "https://doi.org/10.1002/eji.1830240209" @default.
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