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- W2017143761 abstract "SUMMARY Polyoma virus demonstrated a requirement for all of the individual amino acids of Eagle’s minimal essential medium; however, arginine deprivation inhibited virus synthesis to the greatest extent. Early recovery of virus synthesis upon addition of arginine to an arginine-deprived infection indicated that arginine deprivation possibly inhibited a late step of virus synthesis. Arginine deprivation inhibited polyoma virus DNA synthesis by 60%, whereas plaque-forming activity was inhibited approximately 90% during the same period. Arginine deprivation did not affect the number of cells synthesizing structural antigens; however, the encapsidation of virus DNA, dependent upon the synthesis of all structural proteins necessary for virus maturation, was inhibited approximately 90%. A portion of the particles synthesized in arginine-deprived cultures was susceptible to nuclease digestion suggesting incomplete assembly." @default.
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- W2017143761 date "1971-01-01" @default.
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- W2017143761 title "Effects of Arginine Deprivation on Polyoma Virus Infection of Mouse Embryo Cultures" @default.
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- W2017143761 doi "https://doi.org/10.1099/0022-1317-10-1-53" @default.
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