FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2017144791> ?p ?o ?g. }

• W2017144791 endingPage "15044" @default.
• W2017144791 startingPage "15034" @default.
• W2017144791 abstract "The intramolecular reaction of cysteine thiyl radicals with peptide and protein αC−H bonds represents a potential mechanism for irreversible protein oxidation. Here, we have measured absolute rate constants for these reversible hydrogen transfer reactions by means of pulse radiolysis and laser flash photolysis of model peptides. For N-Ac-CysGly6 and N-Ac-CysGly2AspGly3, Cys thiyl radicals abstract hydrogen atoms from Gly with kf = (1.0−1.1) × 105 s−1, generating carbon-centered radicals, while the reverse reaction proceeds with kr = (8.0−8.9) × 105 s−1. The forward reaction shows a normal kinetic isotope effect of kH/kD = 6.9, while the reverse reaction shows a significantly higher normal kinetic isotope effect of 17.6, suggesting a contribution of tunneling. For N-Ac-CysAla2AspAla3, cysteine thiyl radicals abstract hydrogen atoms from Ala with kf = (0.9−1.0) × 104 s−1, while the reverse reaction proceeds with kr = 1.0 × 105 s−1. The order of reactivity, Gly > Ala, is in accord with previous studies on intermolecular reactions of thiyl radicals with these amino acids. The fact that kf < kr suggests some secondary structure of the model peptides, which prevents the adoption of extended conformations, for which calculations of homolytic bond dissociation energies would have predicted kf > kr. Despite kf < kr, model calculations show that intramolecular hydrogen abstraction by Cys thiyl radicals can lead to significant oxidation of other amino acids in the presence of physiologic oxygen concentrations." @default.
• W2017144791 created "2016-06-24" @default.
• W2017144791 creator A5003116967 @default.
• W2017144791 creator A5024842195 @default.
• W2017144791 creator A5030820947 @default.
• W2017144791 creator A5073984454 @default.
• W2017144791 date "2008-10-31" @default.
• W2017144791 modified "2023-10-03" @default.
• W2017144791 title "Reversible Intramolecular Hydrogen Transfer between Cysteine Thiyl Radicals and Glycine and Alanine in Model Peptides: Absolute Rate Constants Derived from Pulse Radiolysis and Laser Flash Photolysis" @default.
• W2017144791 cites W108159369 @default.
• W2017144791 cites W1510914671 @default.
• W2017144791 cites W1816043555 @default.
• W2017144791 cites W1901656938 @default.
• W2017144791 cites W1926950498 @default.
• W2017144791 cites W1975126218 @default.
• W2017144791 cites W1975294627 @default.
• W2017144791 cites W1981050112 @default.
• W2017144791 cites W1981794764 @default.
• W2017144791 cites W1987778904 @default.
• W2017144791 cites W1991553260 @default.
• W2017144791 cites W1993033323 @default.
• W2017144791 cites W2004082179 @default.
• W2017144791 cites W2005472029 @default.
• W2017144791 cites W2006883146 @default.
• W2017144791 cites W2006899749 @default.
• W2017144791 cites W2013635084 @default.
• W2017144791 cites W2017905772 @default.
• W2017144791 cites W2022396361 @default.
• W2017144791 cites W2024456163 @default.
• W2017144791 cites W2025146298 @default.
• W2017144791 cites W2025630877 @default.
• W2017144791 cites W2026721826 @default.
• W2017144791 cites W2031167182 @default.
• W2017144791 cites W2031809615 @default.
• W2017144791 cites W2032839609 @default.
• W2017144791 cites W2037918414 @default.
• W2017144791 cites W2038417066 @default.
• W2017144791 cites W2049485709 @default.
• W2017144791 cites W2053193022 @default.
• W2017144791 cites W2068634959 @default.
• W2017144791 cites W2071982166 @default.
• W2017144791 cites W2081623507 @default.
• W2017144791 cites W2089110536 @default.
• W2017144791 cites W2091491046 @default.
• W2017144791 cites W2108851069 @default.
• W2017144791 cites W2139333356 @default.
• W2017144791 cites W2147609254 @default.
• W2017144791 cites W2149790826 @default.
• W2017144791 cites W2151478644 @default.
• W2017144791 cites W2162663114 @default.
• W2017144791 cites W2950887963 @default.
• W2017144791 cites W2952895369 @default.
• W2017144791 cites W295406538 @default.
• W2017144791 cites W4383700819 @default.
• W2017144791 doi "https://doi.org/10.1021/jp805133u" @default.
• W2017144791 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2662404" @default.
• W2017144791 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18973367" @default.
• W2017144791 hasPublicationYear "2008" @default.
• W2017144791 type Work @default.
• W2017144791 sameAs 2017144791 @default.
• W2017144791 citedByCount "67" @default.
• W2017144791 countsByYear W20171447912012 @default.
• W2017144791 countsByYear W20171447912013 @default.
• W2017144791 countsByYear W20171447912014 @default.
• W2017144791 countsByYear W20171447912015 @default.
• W2017144791 countsByYear W20171447912016 @default.
• W2017144791 countsByYear W20171447912017 @default.
• W2017144791 countsByYear W20171447912018 @default.
• W2017144791 countsByYear W20171447912019 @default.
• W2017144791 countsByYear W20171447912020 @default.
• W2017144791 countsByYear W20171447912021 @default.
• W2017144791 countsByYear W20171447912022 @default.
• W2017144791 countsByYear W20171447912023 @default.
• W2017144791 crossrefType "journal-article" @default.
• W2017144791 hasAuthorship W2017144791A5003116967 @default.
• W2017144791 hasAuthorship W2017144791A5024842195 @default.
• W2017144791 hasAuthorship W2017144791A5030820947 @default.
• W2017144791 hasAuthorship W2017144791A5073984454 @default.
• W2017144791 hasBestOaLocation W20171447912 @default.
• W2017144791 hasConcept C121332964 @default.
• W2017144791 hasConcept C13472781 @default.
• W2017144791 hasConcept C139066938 @default.
• W2017144791 hasConcept C148898269 @default.
• W2017144791 hasConcept C166950319 @default.
• W2017144791 hasConcept C175689099 @default.
• W2017144791 hasConcept C178790620 @default.
• W2017144791 hasConcept C185592680 @default.
• W2017144791 hasConcept C2776640939 @default.
• W2017144791 hasConcept C2780263894 @default.
• W2017144791 hasConcept C32909587 @default.
• W2017144791 hasConcept C54582936 @default.
• W2017144791 hasConcept C58364064 @default.
• W2017144791 hasConcept C62520636 @default.
• W2017144791 hasConcept C66887884 @default.
• W2017144791 hasConcept C69928629 @default.
• W2017144791 hasConcept C71240020 @default.
• W2017144791 hasConcept C75079739 @default.
• W2017144791 hasConcept C75473681 @default.

• next