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- W2017144817 abstract "Studies were conducted to examine the effects of low, yet physiologically relevant, temperatures on murine T lymphocyte responses. Akin to ectothermic vertebrate responses, lectin-induced murine T cell proliferation was previously shown to be ablated at temperatures 10 °C below optimal (i.e. 27 °C); responsiveness at 27 °C was restored by the addition of oleic acid (18:1). The aim of the present study was to address the mechanism involved in such low temperature suppression. Murine splenic CD4+ T lymphocytes stimulated with either αCD3 or SEB exhibited cell death, as opposed to anergy, at 27 °C. However proliferation was observed in the presence of 18:1. Thus low temperature-suppression of murine CD4+ T cells is also mediated through TCR and/or CD3 pathways. Additional studies examining the temporal effects of adding 18:1, as well as temperature shifts, indicated that the cell death induced by stimulation at low temperature was preventable by 18:1." @default.
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- W2017144817 date "1997-07-01" @default.
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- W2017144817 title "Effects of oleic acid on murine CD4+ T cell death and anti-CD3 or superantigen induced proliferation at low temperature" @default.
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- W2017144817 doi "https://doi.org/10.1016/s0145-305x(97)00015-3" @default.
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