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- W2017146501 abstract "The effect of methylmercury on mouse thymocytes was examined using fluorescent dyes for membrane potential and intracellular Ca2+. Methylmercury at concentrations of 1 ωM or higher (up to 30 ωM) produced hyperpolarization in a dose-dependent fashion. Charybdotoxin and quinine, but not 4-aminopyridine and tetraethylammonium, greatly suppressed methylmercury-induced hyperpolarization. Removal of external Ca2+ reduced the degree of hyperpolarization. Pretreatment of thymocytes with A23187 under Ca2+-free conditions abolished the hyperpolarization induced by methylmercury. Under both normal and Ca2+-free conditions methylmercury increased the intracellular concentration of Ca2+. The results suggest that the increase in intracellular Ca2+ is mediated through a Ca2+ release from intracellular stores as well as through influx of external Ca2+. Therefore, it is likely that methylmercury increases the intracellular concentration of Ca2+, resulting in activation of Ca2+-dependent K+ conductance of mouse thymocytes." @default.
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- W2017146501 title "Methylmercury induces Ca2+-dependent hyperpolarization of mouse thymocytes: a flow cytometric study using fluorescent dyes" @default.
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- W2017146501 doi "https://doi.org/10.1016/0926-6917(95)00003-8" @default.
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