FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2017146561> ?p ?o ?g. }

• W2017146561 endingPage "32" @default.
• W2017146561 startingPage "27" @default.
• W2017146561 abstract "Accumulating evidence implicates small vessel cerebrovascular disease, visualized as white matter hyperintensities (WMH) on T2-weighted magnetic resonance imaging, in the pathogenesis and diagnosis of Alzheimer's disease (AD). Cross-sectional volumetric measures of WMH, particularly in the parietal lobes, are associated with increased risk of AD. In the present study, we sought to determine whether the longitudinal regional progression of WMH predicts incident AD above-and-beyond traditional radiological markers of neurodegeneration (i.e., hippocampal atrophy and cortical thickness). Three hundred three nondemented older adults (mean age = 79.24 ± 5.29) received high-resolution magnetic resonance imaging at baseline and then again 4.6 years (standard deviation = 1.01) later. Over the follow-up interval 26 participants progressed to AD. Using structural equation modeling, we calculated latent difference scores of parietal and nonparietal WMH, hippocampus volumes, and cortical thickness values in AD-related regions. Within the structural equation modeling framework, we determined whether baseline or change scores or both predicted AD conversion, while controlling for several time-invariant relevant variables. Smaller baseline hippocampus volume, change in hippocampus volume (i.e., atrophy), higher baseline parietal lobe WMH, and increasing parietal lobe WMH volume but not WMH in other regions or measures of cortical thickness, independently predicted progression to AD. The findings provide strong evidence that regionally accumulating WMH predict AD onset in addition to hallmark neurodegenerative changes typically associated with AD." @default.
• W2017146561 created "2016-06-24" @default.
• W2017146561 creator A5001169375 @default.
• W2017146561 creator A5009639179 @default.
• W2017146561 creator A5010927151 @default.
• W2017146561 creator A5014654967 @default.
• W2017146561 creator A5029303778 @default.
• W2017146561 creator A5032025339 @default.
• W2017146561 creator A5040595080 @default.
• W2017146561 creator A5041371000 @default.
• W2017146561 creator A5060941001 @default.
• W2017146561 creator A5068971185 @default.
• W2017146561 creator A5077632970 @default.
• W2017146561 creator A5079179497 @default.
• W2017146561 date "2015-01-01" @default.
• W2017146561 modified "2023-10-16" @default.
• W2017146561 title "Reconsidering harbingers of dementia: progression of parietal lobe white matter hyperintensities predicts Alzheimer's disease incidence" @default.
• W2017146561 cites W1966100017 @default.
• W2017146561 cites W1969443632 @default.
• W2017146561 cites W1971744915 @default.
• W2017146561 cites W1978316308 @default.
• W2017146561 cites W1981802311 @default.
• W2017146561 cites W1983933902 @default.
• W2017146561 cites W1989696781 @default.
• W2017146561 cites W1991230977 @default.
• W2017146561 cites W1997378060 @default.
• W2017146561 cites W1998886798 @default.
• W2017146561 cites W2008273493 @default.
• W2017146561 cites W2013803050 @default.
• W2017146561 cites W2025578977 @default.
• W2017146561 cites W2031309116 @default.
• W2017146561 cites W2038846578 @default.
• W2017146561 cites W2052742260 @default.
• W2017146561 cites W2055568131 @default.
• W2017146561 cites W2060774463 @default.
• W2017146561 cites W2068338689 @default.
• W2017146561 cites W2068891120 @default.
• W2017146561 cites W2075273600 @default.
• W2017146561 cites W2075348467 @default.
• W2017146561 cites W2089831515 @default.
• W2017146561 cites W2090068727 @default.
• W2017146561 cites W2108410348 @default.
• W2017146561 cites W2112150247 @default.
• W2017146561 cites W2117673398 @default.
• W2017146561 cites W2118900259 @default.
• W2017146561 cites W2128581044 @default.
• W2017146561 cites W2134563219 @default.
• W2017146561 cites W2136210722 @default.
• W2017146561 cites W2147592269 @default.
• W2017146561 cites W2153828345 @default.
• W2017146561 cites W2154732345 @default.
• W2017146561 cites W2156220037 @default.
• W2017146561 cites W2156574403 @default.
• W2017146561 cites W2157054229 @default.
• W2017146561 cites W2157972347 @default.
• W2017146561 cites W2158901540 @default.
• W2017146561 cites W2161938624 @default.
• W2017146561 cites W2171346860 @default.
• W2017146561 cites W2171808809 @default.
• W2017146561 cites W2324768936 @default.
• W2017146561 cites W68826371 @default.
• W2017146561 doi "https://doi.org/10.1016/j.neurobiolaging.2014.07.019" @default.
• W2017146561 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4268124" @default.
• W2017146561 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25155654" @default.
• W2017146561 hasPublicationYear "2015" @default.
• W2017146561 type Work @default.
• W2017146561 sameAs 2017146561 @default.
• W2017146561 citedByCount "191" @default.
• W2017146561 countsByYear W20171465612014 @default.
• W2017146561 countsByYear W20171465612015 @default.
• W2017146561 countsByYear W20171465612016 @default.
• W2017146561 countsByYear W20171465612017 @default.
• W2017146561 countsByYear W20171465612018 @default.
• W2017146561 countsByYear W20171465612019 @default.
• W2017146561 countsByYear W20171465612020 @default.
• W2017146561 countsByYear W20171465612021 @default.
• W2017146561 countsByYear W20171465612022 @default.
• W2017146561 countsByYear W20171465612023 @default.
• W2017146561 crossrefType "journal-article" @default.
• W2017146561 hasAuthorship W2017146561A5001169375 @default.
• W2017146561 hasAuthorship W2017146561A5009639179 @default.
• W2017146561 hasAuthorship W2017146561A5010927151 @default.
• W2017146561 hasAuthorship W2017146561A5014654967 @default.
• W2017146561 hasAuthorship W2017146561A5029303778 @default.
• W2017146561 hasAuthorship W2017146561A5032025339 @default.
• W2017146561 hasAuthorship W2017146561A5040595080 @default.
• W2017146561 hasAuthorship W2017146561A5041371000 @default.
• W2017146561 hasAuthorship W2017146561A5060941001 @default.
• W2017146561 hasAuthorship W2017146561A5068971185 @default.
• W2017146561 hasAuthorship W2017146561A5077632970 @default.
• W2017146561 hasAuthorship W2017146561A5079179497 @default.
• W2017146561 hasBestOaLocation W20171465612 @default.
• W2017146561 hasConcept C126322002 @default.
• W2017146561 hasConcept C126838900 @default.
• W2017146561 hasConcept C143409427 @default.
• W2017146561 hasConcept C146638467 @default.
• W2017146561 hasConcept C15744967 @default.
• W2017146561 hasConcept C164705383 @default.

• next