FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2017148917> ?p ?o ?g. }

• W2017148917 endingPage "2468" @default.
• W2017148917 startingPage "2459" @default.
• W2017148917 abstract "Objective: To determine the mechanism for the reduced polymorphonuclear neutrophil exudation to secondary inflammatory sites in critically ill patients with infection and systemic inflammatory response (sepsis). Design: Prospective cohort study. Setting: Research laboratory and integrated intensive care unit of a tertiary care university-affiliated teaching hospital. Patients: Healthy subjects or critically ill patients with confirmed infection and a systemic inflammatory response (septic patients). Measurements and Main Results: We found that polymorphonuclear neutrophil delivery to a secondary inflammatory site (skin window blisters) is reduced by >70% in humans with sepsis, defined as serious infection and a systemic inflammatory response compared with healthy controls. The expression of the endothelial adhesion molecules intercellular adhesion molecule-1, E-selectin and P-selectin in microvessels from skin biopsies was comparable in the two study groups. Also, CD11a and CD11b levels were equal in circulating polymorphonuclear neutrophils (PMNs) from both study groups. Both adhesion molecules were markedly and equally up-regulated during exudation. Circulating PMNs from septic patients showed marked shedding of L-selectin compared to those of healthy controls, with a corresponding increase in their plasma L-selectin levels. An increased concentration gradient between plasma and exudate fluid was found for tumor necrosis factor-α and interleukin-8 in septic patients, but not for C5a. The phagocytic and bactericidal capacity of septic patient circulating PMNs was higher then in healthy control patients, but these differences were lost after exudation. There were no major differences in oxidative burst or intracellular calcium flux of circulating PMNs from the two study groups. Polymorphonuclear neutrophil exudation primed both responses to different extents. Conclusions: Septic patients deliver fewer PMNs to secondary inflammatory sites. In addition, neutrophil exudation results in loss of the small priming effect for phagocytosis and bactericidal function induced by sepsis. Failure to produce a gradient to C5a and intravascular shedding of L-selectin may be responsible for this sepsis-induced reduction in neutrophil exudation to secondary inflammatory sites." @default.
• W2017148917 created "2016-06-24" @default.
• W2017148917 creator A5030251585 @default.
• W2017148917 creator A5053086214 @default.
• W2017148917 creator A5066282586 @default.
• W2017148917 creator A5068411039 @default.
• W2017148917 creator A5069172853 @default.
• W2017148917 creator A5091724623 @default.
• W2017148917 date "1999-11-01" @default.
• W2017148917 modified "2023-09-26" @default.
• W2017148917 title "Mechanisms for the diminished neutrophil exudation to secondary inflammatory sites in infected patients with a systemic inflammatory response (sepsis)" @default.
• W2017148917 cites W108110864 @default.
• W2017148917 cites W1986362547 @default.
• W2017148917 cites W1991336686 @default.
• W2017148917 cites W1991512363 @default.
• W2017148917 cites W1992317118 @default.
• W2017148917 cites W1993691136 @default.
• W2017148917 cites W2005118831 @default.
• W2017148917 cites W2008515082 @default.
• W2017148917 cites W2017491754 @default.
• W2017148917 cites W2019228039 @default.
• W2017148917 cites W2033179834 @default.
• W2017148917 cites W2037229296 @default.
• W2017148917 cites W2046996547 @default.
• W2017148917 cites W2057905142 @default.
• W2017148917 cites W2064070420 @default.
• W2017148917 cites W2072062048 @default.
• W2017148917 cites W2077634410 @default.
• W2017148917 cites W2079096224 @default.
• W2017148917 cites W2079863540 @default.
• W2017148917 cites W2086780733 @default.
• W2017148917 cites W2088325902 @default.
• W2017148917 cites W2100087148 @default.
• W2017148917 cites W2147665627 @default.
• W2017148917 cites W2271852401 @default.
• W2017148917 cites W2316833134 @default.
• W2017148917 cites W2396361590 @default.
• W2017148917 cites W2400434811 @default.
• W2017148917 cites W2412380956 @default.
• W2017148917 cites W2431696670 @default.
• W2017148917 cites W4293242440 @default.
• W2017148917 doi "https://doi.org/10.1097/00003246-199911000-00023" @default.
• W2017148917 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10579265" @default.
• W2017148917 hasPublicationYear "1999" @default.
• W2017148917 type Work @default.
• W2017148917 sameAs 2017148917 @default.
• W2017148917 citedByCount "47" @default.
• W2017148917 countsByYear W20171489172012 @default.
• W2017148917 countsByYear W20171489172013 @default.
• W2017148917 countsByYear W20171489172014 @default.
• W2017148917 countsByYear W20171489172015 @default.
• W2017148917 countsByYear W20171489172016 @default.
• W2017148917 countsByYear W20171489172017 @default.
• W2017148917 countsByYear W20171489172021 @default.
• W2017148917 countsByYear W20171489172022 @default.
• W2017148917 crossrefType "journal-article" @default.
• W2017148917 hasAuthorship W2017148917A5030251585 @default.
• W2017148917 hasAuthorship W2017148917A5053086214 @default.
• W2017148917 hasAuthorship W2017148917A5066282586 @default.
• W2017148917 hasAuthorship W2017148917A5068411039 @default.
• W2017148917 hasAuthorship W2017148917A5069172853 @default.
• W2017148917 hasAuthorship W2017148917A5091724623 @default.
• W2017148917 hasConcept C11988809 @default.
• W2017148917 hasConcept C17991360 @default.
• W2017148917 hasConcept C203014093 @default.
• W2017148917 hasConcept C2776252253 @default.
• W2017148917 hasConcept C2776914184 @default.
• W2017148917 hasConcept C2777628635 @default.
• W2017148917 hasConcept C2778384902 @default.
• W2017148917 hasConcept C2781090800 @default.
• W2017148917 hasConcept C2909375385 @default.
• W2017148917 hasConcept C71924100 @default.
• W2017148917 hasConceptScore W2017148917C11988809 @default.
• W2017148917 hasConceptScore W2017148917C17991360 @default.
• W2017148917 hasConceptScore W2017148917C203014093 @default.
• W2017148917 hasConceptScore W2017148917C2776252253 @default.
• W2017148917 hasConceptScore W2017148917C2776914184 @default.
• W2017148917 hasConceptScore W2017148917C2777628635 @default.
• W2017148917 hasConceptScore W2017148917C2778384902 @default.
• W2017148917 hasConceptScore W2017148917C2781090800 @default.
• W2017148917 hasConceptScore W2017148917C2909375385 @default.
• W2017148917 hasConceptScore W2017148917C71924100 @default.
• W2017148917 hasIssue "11" @default.
• W2017148917 hasLocation W20171489171 @default.
• W2017148917 hasLocation W20171489172 @default.
• W2017148917 hasOpenAccess W2017148917 @default.
• W2017148917 hasPrimaryLocation W20171489171 @default.
• W2017148917 hasRelatedWork W1571778651 @default.
• W2017148917 hasRelatedWork W1967031337 @default.
• W2017148917 hasRelatedWork W1972296635 @default.
• W2017148917 hasRelatedWork W199655548 @default.
• W2017148917 hasRelatedWork W1997734131 @default.
• W2017148917 hasRelatedWork W2006200448 @default.
• W2017148917 hasRelatedWork W2299895494 @default.
• W2017148917 hasRelatedWork W2765915784 @default.
• W2017148917 hasRelatedWork W4255768744 @default.
• W2017148917 hasRelatedWork W2126777759 @default.
• W2017148917 hasVolume "27" @default.

• next