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- W2017150962 abstract "Despite the use of statins for prevention of cardiovascular events, a residual risk remains in part due to persisting abnormalities on lipids. For decades, niacin has been used for the management of dyslipidemia, it improves multiple lipid parameters and is the most potent drug available to increase HDL-C. Niacin, either in monotherapy or in combination with other lipid-lowering agents, decreases the risk of cardiovascular events. However, its use is limited by the high incidence of flushing, even with the extensed-release formulation. Laropiprant, a selective antagonist of prostaglandin D2 receptor 1, is effective in reducing niacin-induced flushing, without affecting thelipid effects of niacin. The available data on a single-tablet combination of niacin and laropiprant are promising to allow more patients to achieve the therapeutic niacin dose of 2 g per day in clinical practice. However, the niacin/ laropiprant combination does not completely eliminate niacin-flushing side effects and this treatment requires careful instructions to the patient. The ongoing clinical trial, HPS2-THRIVE, will provide important information on the efficacy of extended-release niacin/laropiprant for reducing cardiovascular events, as well as on the long-term safety of this drug." @default.
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- W2017150962 date "2010-12-01" @default.
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- W2017150962 title "Extended-release niacin and laropiprant in the management of dyslipidemias" @default.
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- W2017150962 doi "https://doi.org/10.2217/clp.10.66" @default.
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