FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2017155332> ?p ?o ?g. }

• W2017155332 endingPage "e27667" @default.
• W2017155332 startingPage "e27667" @default.
• W2017155332 abstract "Several signaling pathways control blood cell (hemocyte) development in the Drosophila lymph gland. Mechanisms that modulate and integrate these signals are poorly understood. Here we report that mutation in a conserved endocytic protein Asrij affects signal transmission and causes aberrant lymph gland hematopoiesis. Mammalian Asrij (Ociad1) is expressed in stem cells of the blood vascular system and is implicated in several cancers. We found that Drosophila Asrij is a pan-hemocyte marker and localizes to a subset of endocytic vesicles. Loss of asrij causes hyperproliferation of lymph gland lobes coupled with increased hemocyte differentiation, thereby depleting the pool of quiescent hemocyte precursors. This co-relates with fewer Col+ cells in the hematopoietic stem cell niche of asrij mutants. Asrij null mutants also show excess specification of crystal cells that express the RUNX factor Lozenge (Lz), a target of Notch signaling. Asrij mutant lymph glands show increased N in sorting endosomes suggesting aberrant trafficking. In vitro assays also show impaired traffic of fluorescent probes in asrij null hemocytes. Taken together our data suggest a role for Asrij in causing increased Notch signaling thereby affecting hemocyte differentiation. Thus, conserved endocytic functions may control blood cell progenitor quiescence and differentiation." @default.
• W2017155332 created "2016-06-24" @default.
• W2017155332 creator A5004447867 @default.
• W2017155332 creator A5062553875 @default.
• W2017155332 creator A5067518322 @default.
• W2017155332 creator A5077336721 @default.
• W2017155332 date "2011-11-14" @default.
• W2017155332 modified "2023-09-26" @default.
• W2017155332 title "Asrij Maintains the Stem Cell Niche and Controls Differentiation during Drosophila Lymph Gland Hematopoiesis" @default.
• W2017155332 cites W105826028 @default.
• W2017155332 cites W1245819034 @default.
• W2017155332 cites W1509376831 @default.
• W2017155332 cites W1595935608 @default.
• W2017155332 cites W1675105744 @default.
• W2017155332 cites W1932777057 @default.
• W2017155332 cites W1964846910 @default.
• W2017155332 cites W1967164702 @default.
• W2017155332 cites W1972127223 @default.
• W2017155332 cites W1972168412 @default.
• W2017155332 cites W1975971309 @default.
• W2017155332 cites W1977962361 @default.
• W2017155332 cites W1978807862 @default.
• W2017155332 cites W1982650114 @default.
• W2017155332 cites W1984980675 @default.
• W2017155332 cites W1994528729 @default.
• W2017155332 cites W1997012891 @default.
• W2017155332 cites W2003192606 @default.
• W2017155332 cites W2007215986 @default.
• W2017155332 cites W2009594373 @default.
• W2017155332 cites W2013881612 @default.
• W2017155332 cites W2014987608 @default.
• W2017155332 cites W2017423460 @default.
• W2017155332 cites W2021713419 @default.
• W2017155332 cites W2023100673 @default.
• W2017155332 cites W2030854565 @default.
• W2017155332 cites W2034270461 @default.
• W2017155332 cites W2035478311 @default.
• W2017155332 cites W2037677811 @default.
• W2017155332 cites W2040236732 @default.
• W2017155332 cites W2047653899 @default.
• W2017155332 cites W2048408307 @default.
• W2017155332 cites W2053873619 @default.
• W2017155332 cites W2055204695 @default.
• W2017155332 cites W2064935470 @default.
• W2017155332 cites W2067744084 @default.
• W2017155332 cites W2068010400 @default.
• W2017155332 cites W2069422711 @default.
• W2017155332 cites W2073938143 @default.
• W2017155332 cites W2082644318 @default.
• W2017155332 cites W2085490483 @default.
• W2017155332 cites W2086324585 @default.
• W2017155332 cites W2092067368 @default.
• W2017155332 cites W2096657097 @default.
• W2017155332 cites W2098321105 @default.
• W2017155332 cites W2104315543 @default.
• W2017155332 cites W2105214962 @default.
• W2017155332 cites W2109567661 @default.
• W2017155332 cites W2110643873 @default.
• W2017155332 cites W2114340303 @default.
• W2017155332 cites W2116805218 @default.
• W2017155332 cites W2118642448 @default.
• W2017155332 cites W2128573075 @default.
• W2017155332 cites W2131561091 @default.
• W2017155332 cites W2141932361 @default.
• W2017155332 cites W2142375040 @default.
• W2017155332 cites W2143647823 @default.
• W2017155332 cites W2146117749 @default.
• W2017155332 cites W2157791218 @default.
• W2017155332 cites W2159601147 @default.
• W2017155332 cites W2227087586 @default.
• W2017155332 cites W2301662884 @default.
• W2017155332 cites W2335252520 @default.
• W2017155332 doi "https://doi.org/10.1371/journal.pone.0027667" @default.
• W2017155332 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3318084" @default.
• W2017155332 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22110713" @default.
• W2017155332 hasPublicationYear "2011" @default.
• W2017155332 type Work @default.
• W2017155332 sameAs 2017155332 @default.
• W2017155332 citedByCount "39" @default.
• W2017155332 countsByYear W20171553322012 @default.
• W2017155332 countsByYear W20171553322013 @default.
• W2017155332 countsByYear W20171553322014 @default.
• W2017155332 countsByYear W20171553322015 @default.
• W2017155332 countsByYear W20171553322016 @default.
• W2017155332 countsByYear W20171553322017 @default.
• W2017155332 countsByYear W20171553322018 @default.
• W2017155332 countsByYear W20171553322019 @default.
• W2017155332 countsByYear W20171553322020 @default.
• W2017155332 countsByYear W20171553322021 @default.
• W2017155332 countsByYear W20171553322022 @default.
• W2017155332 crossrefType "journal-article" @default.
• W2017155332 hasAuthorship W2017155332A5004447867 @default.
• W2017155332 hasAuthorship W2017155332A5062553875 @default.
• W2017155332 hasAuthorship W2017155332A5067518322 @default.
• W2017155332 hasAuthorship W2017155332A5077336721 @default.
• W2017155332 hasBestOaLocation W20171553321 @default.
• W2017155332 hasConcept C102747710 @default.
• W2017155332 hasConcept C104317684 @default.

• next