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- W2017156982 abstract "1. Interaction between topical isoprenaline and timolol on intraocular pressure was studied in conscious rabbits through changes of the dose-response curves. 2. Both drugs caused a dose-dependent fall of intraocular pressure mainly by reducing the aqueous humour formation. 3. When combined, timolol increased the response to submaximal concentrations of isoprenaline as well as EC50 (from 2.06 x 10(-3) M to 3.63 x 10(-3) M) and slope (from 1.21 to 1.89), but peak response to isoprenaline remained unchanged. 4. Discordance between experimental and theoretical additive curves as well as an interaction index smaller than 1 show that the interaction between both drugs is synergistic." @default.
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- W2017156982 date "1993-03-01" @default.
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- W2017156982 title "Evidence for a synergistic interaction between isoprenaline and timolol on intraocular pressure in conscious rabbits" @default.
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- W2017156982 doi "https://doi.org/10.1016/0306-3623(93)90334-t" @default.
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