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• W2017159766 abstract "To evaluate the acute toxicity of carboxymethyl chitosan-2, 2' ethylenedioxy bis-ethylamine-folate (CMC-EDBE-FA) and as well as possible effect on microbial growth and in vitro cell cyto-toxicity.CMC-EDBE-FA was prepared on basis of carboxymethyl chitosan tagged with folic acid by covalently linkage through 2, 2' ethylenedioxy bis-ethylamine. In vivo acute toxicity, in vitro cyto-toxicity and antimicrobial activity of CMC-EDBE-FA nanoparticle were determined.Vancomycin exhibited the antibacterial activity against vancomycin sensitive Staphylococcus aureus, but CMC-EDBE-FA nanoparticle did not give any antibacterial activity as evidenced by minimal inhibitory concentration (MIC), minimal bactericidal concentration (MBC), disc agar diffusion (DAD) and killing kinetic assay. Further, the CMC-EDBE-FA nanoparticle showed no signs of in vivo acute toxicity up to a dose level of 1 000 mg/kg p.o., and as well as in vitro cyto-toxicity up to 250 µg/mL.These findings suggest that CMC-EDBE-FA nanoparticle is expected to be safe for biomedical applications." @default.
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• W2017159766 date "2012-03-01" @default.
• W2017159766 modified "2023-09-27" @default.
• W2017159766 title "Biocompatibility of folate–modified chitosan nanoparticles" @default.
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• W2017159766 doi "https://doi.org/10.1016/s2221-1691(12)60044-6" @default.
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