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- W2017161034 abstract "Post-replicative mismatch repair in humans utilises the hMSH2, hMSH6, hMSH3, hMLH1 and hPMS2 genes and possibly the newly identified hMLH3 gene. Recently, a link has been established between hMSH6 mutations and ‘atypical’ hereditary non-polyposis colon cancer (HNPCC) with an increased incidence of endometrial cancers. To satisfy the need for a diagnostic test capable of differentiating between pathogenic mutations and polymorphisms, several functional assays that fulfil these criteria have been described. These should allow for better diagnosis of HNPCC." @default.
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- W2017161034 date "2000-04-01" @default.
- W2017161034 modified "2023-10-10" @default.
- W2017161034 title "Mismatch repair defects in cancer" @default.
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- W2017161034 doi "https://doi.org/10.1016/s0959-437x(00)00066-6" @default.
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