FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2017161041> ?p ?o ?g. }

• W2017161041 endingPage "421" @default.
• W2017161041 startingPage "413" @default.
• W2017161041 abstract "Lafora disease is a progressive myoclonus epilepsy caused by mutations in the EPM2A gene encoding laforin or in the EPM2B gene encoding malin. It is characterized by the presence of polyglucosan intracellular inclusion bodies (Lafora bodies) in brain and other tissues. Targeted disruption of Epm2a or Epm2b genes in mice produced widespread neuronal degeneration and accumulation of Lafora bodies in neuronal and nonneuronal tissues. Here we analyzed the neurologic alterations produced by disruption of the laforin gene in Epm2a mice and compared them to those in malin-deficient mice. Both Epm2a and Epm2b mice showed altered motor activity, impaired motor coordination, abnormal hind limb clasping, and episodic memory deficits. Epm2a mice also had tonic-clonic seizures, whereas both Epm2a and Epm2b mice had spontaneous single spikes, spike-wave, polyspikes, and polyspike-wave complexes with correlated myoclonic jerks. Neurologic alterations observed in the mutants were comparable and correlated with the accumulation of abundant Lafora bodies in the cerebral cortex, the hippocampus, the basal ganglia, the cerebellum, and the brainstem, suggesting that these inclusions could cause cognitive and behavioral deterioration. Thus, both Epm2a and Epm2b mice exhibit many pathologic aspects seen in patients with Lafora disease and may be valuable for the study of this disorder." @default.
• W2017161041 created "2016-06-24" @default.
• W2017161041 creator A5032421860 @default.
• W2017161041 creator A5052276722 @default.
• W2017161041 creator A5063945536 @default.
• W2017161041 creator A5080274904 @default.
• W2017161041 creator A5083768205 @default.
• W2017161041 creator A5089447741 @default.
• W2017161041 date "2012-05-01" @default.
• W2017161041 modified "2023-10-15" @default.
• W2017161041 title "Laforin and Malin Deletions in Mice Produce Similar Neurologic Impairments" @default.
• W2017161041 cites W118722484 @default.
• W2017161041 cites W1584056801 @default.
• W2017161041 cites W1964695375 @default.
• W2017161041 cites W1973421354 @default.
• W2017161041 cites W1985790212 @default.
• W2017161041 cites W2000129674 @default.
• W2017161041 cites W2016631802 @default.
• W2017161041 cites W2018604296 @default.
• W2017161041 cites W2021901516 @default.
• W2017161041 cites W2031212282 @default.
• W2017161041 cites W2033882290 @default.
• W2017161041 cites W2037610573 @default.
• W2017161041 cites W2038132994 @default.
• W2017161041 cites W2049852307 @default.
• W2017161041 cites W2052743974 @default.
• W2017161041 cites W2091000925 @default.
• W2017161041 cites W2093476689 @default.
• W2017161041 cites W2102873804 @default.
• W2017161041 cites W2104504339 @default.
• W2017161041 cites W2109699278 @default.
• W2017161041 cites W2110601384 @default.
• W2017161041 cites W2115316120 @default.
• W2017161041 cites W2118393368 @default.
• W2017161041 cites W2126322967 @default.
• W2017161041 cites W2126722763 @default.
• W2017161041 cites W2131712753 @default.
• W2017161041 cites W2131872983 @default.
• W2017161041 cites W2137181909 @default.
• W2017161041 cites W2140357048 @default.
• W2017161041 cites W2144496034 @default.
• W2017161041 cites W2145780431 @default.
• W2017161041 cites W2145843041 @default.
• W2017161041 cites W2149938389 @default.
• W2017161041 cites W2161825563 @default.
• W2017161041 cites W2164924935 @default.
• W2017161041 cites W2181285684 @default.
• W2017161041 cites W2793634050 @default.
• W2017161041 cites W4297950801 @default.
• W2017161041 cites W84932982 @default.
• W2017161041 doi "https://doi.org/10.1097/nen.0b013e318253350f" @default.
• W2017161041 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22487859" @default.
• W2017161041 hasPublicationYear "2012" @default.
• W2017161041 type Work @default.
• W2017161041 sameAs 2017161041 @default.
• W2017161041 citedByCount "39" @default.
• W2017161041 countsByYear W20171610412013 @default.
• W2017161041 countsByYear W20171610412014 @default.
• W2017161041 countsByYear W20171610412015 @default.
• W2017161041 countsByYear W20171610412016 @default.
• W2017161041 countsByYear W20171610412017 @default.
• W2017161041 countsByYear W20171610412018 @default.
• W2017161041 countsByYear W20171610412019 @default.
• W2017161041 countsByYear W20171610412020 @default.
• W2017161041 countsByYear W20171610412021 @default.
• W2017161041 countsByYear W20171610412022 @default.
• W2017161041 countsByYear W20171610412023 @default.
• W2017161041 crossrefType "journal-article" @default.
• W2017161041 hasAuthorship W2017161041A5032421860 @default.
• W2017161041 hasAuthorship W2017161041A5052276722 @default.
• W2017161041 hasAuthorship W2017161041A5063945536 @default.
• W2017161041 hasAuthorship W2017161041A5080274904 @default.
• W2017161041 hasAuthorship W2017161041A5083768205 @default.
• W2017161041 hasAuthorship W2017161041A5089447741 @default.
• W2017161041 hasBestOaLocation W20171610411 @default.
• W2017161041 hasConcept C11960822 @default.
• W2017161041 hasConcept C126322002 @default.
• W2017161041 hasConcept C169760540 @default.
• W2017161041 hasConcept C178666793 @default.
• W2017161041 hasConcept C2776538686 @default.
• W2017161041 hasConcept C2776925932 @default.
• W2017161041 hasConcept C2777280662 @default.
• W2017161041 hasConcept C2779134260 @default.
• W2017161041 hasConcept C2779483572 @default.
• W2017161041 hasConcept C2779652256 @default.
• W2017161041 hasConcept C2781041448 @default.
• W2017161041 hasConcept C2781161787 @default.
• W2017161041 hasConcept C2781467325 @default.
• W2017161041 hasConcept C2910982124 @default.
• W2017161041 hasConcept C2984863031 @default.
• W2017161041 hasConcept C54355233 @default.
• W2017161041 hasConcept C71924100 @default.
• W2017161041 hasConcept C86803240 @default.
• W2017161041 hasConceptScore W2017161041C11960822 @default.
• W2017161041 hasConceptScore W2017161041C126322002 @default.
• W2017161041 hasConceptScore W2017161041C169760540 @default.
• W2017161041 hasConceptScore W2017161041C178666793 @default.
• W2017161041 hasConceptScore W2017161041C2776538686 @default.

• next