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- W2017161741 abstract "This Review highlights how understanding the mechanisms by which viruses evade and subvert host signalling by pattern-recognition receptors has provided insights into the function of these signalling pathways, the host proteins that are involved and ways in which the pathways might be manipulated therapeutically. The expression of pattern-recognition receptors (PRRs) by immune and tissue cells provides the host with the ability to detect and respond to infection by viruses and other microorganisms. Significant progress has been made from studying this area, including the identification of PRRs, such as Toll-like receptors and RIG-I-like receptors, and the description of the molecular basis of their signalling pathways, which lead to the production of interferons and other cytokines. In parallel, common mechanisms used by viruses to evade PRR-mediated responses or to actively subvert these pathways for their own benefit are emerging. Accumulating evidence on how viral infection and PRR signalling pathways intersect is providing further insights into the function of the pathways involved, their constituent proteins and ways in which they could be manipulated therapeutically." @default.
- W2017161741 created "2016-06-24" @default.
- W2017161741 creator A5011747545 @default.
- W2017161741 creator A5024606616 @default.
- W2017161741 date "2008-12-01" @default.
- W2017161741 modified "2023-10-09" @default.
- W2017161741 title "Viral evasion and subversion of pattern-recognition receptor signalling" @default.
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