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- W2017163651 abstract "Although arterial conduits are widely used and have improved the long-term results of coronary artery bypass grafting, vein grafts remain important additional conduits in coronary surgery. Newer studies show a saphenous vein graft patency of 60% or more at 10 years postoperatively. The pathology of vein graft disease consists of thrombosis, neointimal hyperplasia, and vein graft atherosclerosis, which limit graft longevity. Therapeutic strategies to prevent vein graft disease include external stenting, pharmacotherapy, and gene therapy. The potential benefits of a pharmacologic approach are as follows: (1) Drugs with a broad clinical experience can be used; (2) side effects of systemic application can be minimized by local therapy; and (3) no vascular injury, such as pressurizing the vein for a viral transfection approach, is necessary. The different sites for pharmacotherapy in vein graft disease are reviewed in this article." @default.
- W2017163651 created "2016-06-24" @default.
- W2017163651 creator A5021108407 @default.
- W2017163651 date "2006-05-01" @default.
- W2017163651 modified "2023-10-15" @default.
- W2017163651 title "Pharmacologic inhibition of vein graft neointimal hyperplasia" @default.
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- W2017163651 doi "https://doi.org/10.1016/j.jtcvs.2005.11.043" @default.
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