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- W2017163763 abstract "In chronic renal disease, the synthesis of the kidney hormone, 1,25-dihydroxyvitamin D<sub>3</sub>(1,25-[OH]<sub>2</sub>D<sub>3</sub>), is impaired, thus contributing to the development of renal osteodystrophy. The clinical use of 1,25-[OH]<sub>2</sub>D<sub>3</sub>is limited, due to the complexity and expense of its chemical synthesis. This study reports the use of 1-α-hydroxyvitamin D<sub>3</sub>(1-α-OH-D<sub>3</sub>), an active analogue of (1,25-[OH]<sub>2</sub>D<sub>3</sub>, in eight patients with chronic renal failure, five of whom were undergoing long-term hemodialysis. The drug was given orally for 6 to 260 days at a dosage of 1μg to 4μg/day. Short-term (21 days) balance studies showed an increase in intestinal calcium absorption and a simultaneous fall in serum parathyroid hormone levels during administration of 1-α-OH-D<sub>3</sub>. In two long-term studies (160 and 260 days), roentgenographic improvement of renal osteodystrophy was seen after 45 and 185 days, respectively. The data indicate that 1-α-OH-D<sub>3</sub>holds considerable promise for the prevention and treatment of renal osteodystrophy. (<i>JAMA</i>234:47-52, 1975)" @default.
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- W2017163763 date "1975-10-06" @default.
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- W2017163763 title "1-a-Hydroxyvitamin D3 in Chronic Renal Failure" @default.
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- W2017163763 doi "https://doi.org/10.1001/jama.1975.03260140049013" @default.
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