FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2017164563> ?p ?o ?g. }

• W2017164563 endingPage "20" @default.
• W2017164563 startingPage "11" @default.
• W2017164563 abstract "Mobilization of intracellular calcium is an indispensable step of fertilization-induced egg activation. Recently, this process has been shown to require the sequential activation of Src family tyrosine kinases, phospholipase Cgamma (PLCgamma), and inositol-1,4,5-trisphosphate (IP3)-dependent receptor of endoplasmic reticulum. In the present study, we made an attempt to recapitulate the early events of egg activation by stimulating Src kinase activity in the cell-free extracts of Xenopus eggs. We found that enhanced Src kinase activity can initiate calcium response of low magnitude in cytostatic factor (CSF)-arrested mitotic extracts without releasing them into interphase. The addition of catalytically active recombinant Src kinase, as well as the activation of endogenous Xenopus Src family kinase by hydrogen peroxide (H2O2), increased total tyrosine phosphorylation, tyrosine phosphorylation of PLCgamma, and IP3 production in the extracts. The treatment with the Src family kinase-specific inhibitor, PP1, or PLC inhibitor, U73122, or IP3 receptor antagonist, heparin, prevented calcium release in the extracts. We conclude, therefore, that possible mechanism of Src/H2O2 action in the extracts might involve tyrosine phosphorylation and activation of PLCgamma, accompanied by the increase in IP3 content and subsequent calcium release from IP3-regulated calcium stores. These results also suggest that monitoring calcium signals induced in the Xenopus egg extracts by various components of signaling pathways may provide a particularly useful approach to investigating their role in the signal transduction." @default.
• W2017164563 created "2016-06-24" @default.
• W2017164563 creator A5060099887 @default.
• W2017164563 creator A5065317007 @default.
• W2017164563 creator A5075964436 @default.
• W2017164563 creator A5078036127 @default.
• W2017164563 date "2002-07-01" @default.
• W2017164563 modified "2023-10-09" @default.
• W2017164563 title "Src kinase induces calcium release in Xenopus egg extracts via PLCγ and IP3-dependent mechanism" @default.
• W2017164563 cites W1505994816 @default.
• W2017164563 cites W1524196422 @default.
• W2017164563 cites W1603199903 @default.
• W2017164563 cites W1838598929 @default.
• W2017164563 cites W1973787025 @default.
• W2017164563 cites W1986605032 @default.
• W2017164563 cites W1987119400 @default.
• W2017164563 cites W1997205949 @default.
• W2017164563 cites W1997836839 @default.
• W2017164563 cites W1998539827 @default.
• W2017164563 cites W2007278837 @default.
• W2017164563 cites W2015293062 @default.
• W2017164563 cites W2020784937 @default.
• W2017164563 cites W2023498823 @default.
• W2017164563 cites W2031017668 @default.
• W2017164563 cites W2044804726 @default.
• W2017164563 cites W2045169421 @default.
• W2017164563 cites W2058127710 @default.
• W2017164563 cites W2061098495 @default.
• W2017164563 cites W2069017928 @default.
• W2017164563 cites W2072918638 @default.
• W2017164563 cites W2085664820 @default.
• W2017164563 cites W2087654747 @default.
• W2017164563 cites W2088381646 @default.
• W2017164563 cites W2090239388 @default.
• W2017164563 cites W2100837269 @default.
• W2017164563 cites W2101731958 @default.
• W2017164563 cites W2129032725 @default.
• W2017164563 cites W2137901143 @default.
• W2017164563 cites W2155495069 @default.
• W2017164563 cites W2156320225 @default.
• W2017164563 cites W2163248783 @default.
• W2017164563 cites W2168373511 @default.
• W2017164563 cites W2169235449 @default.
• W2017164563 cites W2184717106 @default.
• W2017164563 cites W2336667672 @default.
• W2017164563 cites W4322388553 @default.
• W2017164563 cites W935855719 @default.
• W2017164563 doi "https://doi.org/10.1016/s0143-4160(02)00078-7" @default.
• W2017164563 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12127058" @default.
• W2017164563 hasPublicationYear "2002" @default.
• W2017164563 type Work @default.
• W2017164563 sameAs 2017164563 @default.
• W2017164563 citedByCount "55" @default.
• W2017164563 countsByYear W20171645632012 @default.
• W2017164563 countsByYear W20171645632013 @default.
• W2017164563 countsByYear W20171645632014 @default.
• W2017164563 countsByYear W20171645632015 @default.
• W2017164563 countsByYear W20171645632016 @default.
• W2017164563 countsByYear W20171645632017 @default.
• W2017164563 countsByYear W20171645632018 @default.
• W2017164563 countsByYear W20171645632019 @default.
• W2017164563 countsByYear W20171645632023 @default.
• W2017164563 crossrefType "journal-article" @default.
• W2017164563 hasAuthorship W2017164563A5060099887 @default.
• W2017164563 hasAuthorship W2017164563A5065317007 @default.
• W2017164563 hasAuthorship W2017164563A5075964436 @default.
• W2017164563 hasAuthorship W2017164563A5078036127 @default.
• W2017164563 hasConcept C108636557 @default.
• W2017164563 hasConcept C11960822 @default.
• W2017164563 hasConcept C183141693 @default.
• W2017164563 hasConcept C184235292 @default.
• W2017164563 hasConcept C185592680 @default.
• W2017164563 hasConcept C197153747 @default.
• W2017164563 hasConcept C2777553839 @default.
• W2017164563 hasConcept C42362537 @default.
• W2017164563 hasConcept C55493867 @default.
• W2017164563 hasConcept C62478195 @default.
• W2017164563 hasConcept C86803240 @default.
• W2017164563 hasConcept C95444343 @default.
• W2017164563 hasConceptScore W2017164563C108636557 @default.
• W2017164563 hasConceptScore W2017164563C11960822 @default.
• W2017164563 hasConceptScore W2017164563C183141693 @default.
• W2017164563 hasConceptScore W2017164563C184235292 @default.
• W2017164563 hasConceptScore W2017164563C185592680 @default.
• W2017164563 hasConceptScore W2017164563C197153747 @default.
• W2017164563 hasConceptScore W2017164563C2777553839 @default.
• W2017164563 hasConceptScore W2017164563C42362537 @default.
• W2017164563 hasConceptScore W2017164563C55493867 @default.
• W2017164563 hasConceptScore W2017164563C62478195 @default.
• W2017164563 hasConceptScore W2017164563C86803240 @default.
• W2017164563 hasConceptScore W2017164563C95444343 @default.
• W2017164563 hasIssue "1" @default.
• W2017164563 hasLocation W20171645631 @default.
• W2017164563 hasLocation W20171645632 @default.
• W2017164563 hasOpenAccess W2017164563 @default.
• W2017164563 hasPrimaryLocation W20171645631 @default.
• W2017164563 hasRelatedWork W113286307 @default.
• W2017164563 hasRelatedWork W1899903779 @default.

• next