FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2017165105> ?p ?o ?g. }

• W2017165105 endingPage "307" @default.
• W2017165105 startingPage "295" @default.
• W2017165105 abstract "To investigate the safety pharmacology of a novel fluoroquinolone antibiotic agent, DW‐224a, on the vital functions, we studied its effects on the central nervous system, cardiovascular system and respiratory system. To determine the effects on the central nervous system, we used a modified Irwin's test at each time point after oral administration of DW‐224a to mice. In this test, we found that the treatment of test article had no effects on motor activity, behavioral changes, coordination, and sensory/motor reflex responses. The effects of DW‐224a on the cardiovascular system were evaluated by the use of a telemetry system in beagle dogs. At 360 min post‐DW‐224a (100 mg/kg) administration, QT interval prolongation was observed. However, there were no changes in heart rate, blood pressure, and electrocardiogram at all doses and each time points with the exception of QT‐interval prolongation as compared to the vehicle treated group. In experiments designed to determine the changes of respiratory function in rats, we found no changes at all doses and time points. We investigated the effects of DW‐224a on the human ether‐à‐go‐go‐related gene (hERG) mediated potassium currents to evaluate its potential to induce QT interval prolongation. When whole cell patch‐clamp electrophysiology was used, DW‐224a inhibited hERG currents with IC50 of 218.12 ± 39.51 µM though its effect was less potent than that of E‐4031, a positive control drug. Our data suggested that DW‐224a showed no adverse effects on the central nervous system, cardiovascular system, and respiratory system, with the exception of the effect on the QT interval prolongation." @default.
• W2017165105 created "2016-06-24" @default.
• W2017165105 creator A5004993146 @default.
• W2017165105 creator A5039880005 @default.
• W2017165105 creator A5041548931 @default.
• W2017165105 creator A5073909875 @default.
• W2017165105 date "2004-01-01" @default.
• W2017165105 modified "2023-10-14" @default.
• W2017165105 title "Safety Pharmacology of DW‐224a, A Novel Fluoroquinolone Antibiotic Agent" @default.
• W2017165105 cites W1977106096 @default.
• W2017165105 cites W1979924020 @default.
• W2017165105 cites W1989507711 @default.
• W2017165105 cites W1993515016 @default.
• W2017165105 cites W2009667219 @default.
• W2017165105 cites W2013500670 @default.
• W2017165105 cites W2021347063 @default.
• W2017165105 cites W2021438486 @default.
• W2017165105 cites W2050590316 @default.
• W2017165105 cites W2068879317 @default.
• W2017165105 cites W2074705578 @default.
• W2017165105 cites W2089087883 @default.
• W2017165105 cites W2099125976 @default.
• W2017165105 cites W2127689004 @default.
• W2017165105 cites W2159153323 @default.
• W2017165105 cites W2169922352 @default.
• W2017165105 cites W4242949523 @default.
• W2017165105 doi "https://doi.org/10.1081/dct-200039708" @default.
• W2017165105 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15573468" @default.
• W2017165105 hasPublicationYear "2004" @default.
• W2017165105 type Work @default.
• W2017165105 sameAs 2017165105 @default.
• W2017165105 citedByCount "15" @default.
• W2017165105 countsByYear W20171651052013 @default.
• W2017165105 countsByYear W20171651052015 @default.
• W2017165105 countsByYear W20171651052016 @default.
• W2017165105 countsByYear W20171651052017 @default.
• W2017165105 countsByYear W20171651052018 @default.
• W2017165105 countsByYear W20171651052019 @default.
• W2017165105 countsByYear W20171651052021 @default.
• W2017165105 crossrefType "journal-article" @default.
• W2017165105 hasAuthorship W2017165105A5004993146 @default.
• W2017165105 hasAuthorship W2017165105A5039880005 @default.
• W2017165105 hasAuthorship W2017165105A5041548931 @default.
• W2017165105 hasAuthorship W2017165105A5073909875 @default.
• W2017165105 hasConcept C118441451 @default.
• W2017165105 hasConcept C126322002 @default.
• W2017165105 hasConcept C185263204 @default.
• W2017165105 hasConcept C197934379 @default.
• W2017165105 hasConcept C2776190711 @default.
• W2017165105 hasConcept C2776820430 @default.
• W2017165105 hasConcept C2777953023 @default.
• W2017165105 hasConcept C2779362680 @default.
• W2017165105 hasConcept C2780035454 @default.
• W2017165105 hasConcept C42219234 @default.
• W2017165105 hasConcept C529278444 @default.
• W2017165105 hasConcept C71924100 @default.
• W2017165105 hasConcept C83743174 @default.
• W2017165105 hasConcept C84393581 @default.
• W2017165105 hasConcept C98274493 @default.
• W2017165105 hasConceptScore W2017165105C118441451 @default.
• W2017165105 hasConceptScore W2017165105C126322002 @default.
• W2017165105 hasConceptScore W2017165105C185263204 @default.
• W2017165105 hasConceptScore W2017165105C197934379 @default.
• W2017165105 hasConceptScore W2017165105C2776190711 @default.
• W2017165105 hasConceptScore W2017165105C2776820430 @default.
• W2017165105 hasConceptScore W2017165105C2777953023 @default.
• W2017165105 hasConceptScore W2017165105C2779362680 @default.
• W2017165105 hasConceptScore W2017165105C2780035454 @default.
• W2017165105 hasConceptScore W2017165105C42219234 @default.
• W2017165105 hasConceptScore W2017165105C529278444 @default.
• W2017165105 hasConceptScore W2017165105C71924100 @default.
• W2017165105 hasConceptScore W2017165105C83743174 @default.
• W2017165105 hasConceptScore W2017165105C84393581 @default.
• W2017165105 hasConceptScore W2017165105C98274493 @default.
• W2017165105 hasIssue "4" @default.
• W2017165105 hasLocation W20171651051 @default.
• W2017165105 hasLocation W20171651052 @default.
• W2017165105 hasOpenAccess W2017165105 @default.
• W2017165105 hasPrimaryLocation W20171651051 @default.
• W2017165105 hasRelatedWork W1607085126 @default.
• W2017165105 hasRelatedWork W179284800 @default.
• W2017165105 hasRelatedWork W1881751277 @default.
• W2017165105 hasRelatedWork W1981726703 @default.
• W2017165105 hasRelatedWork W1995527760 @default.
• W2017165105 hasRelatedWork W2046508051 @default.
• W2017165105 hasRelatedWork W2063274861 @default.
• W2017165105 hasRelatedWork W2343673409 @default.
• W2017165105 hasRelatedWork W2362225904 @default.
• W2017165105 hasRelatedWork W2581748859 @default.
• W2017165105 hasVolume "27" @default.
• W2017165105 isParatext "false" @default.
• W2017165105 isRetracted "false" @default.
• W2017165105 magId "2017165105" @default.
• W2017165105 workType "article" @default.