FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2017166446> ?p ?o ?g. }

• W2017166446 endingPage "AB236" @default.
• W2017166446 startingPage "AB236" @default.
• W2017166446 abstract "Acute pancreatitis is a relatively common and potentially serious complication of ERCP and related interventions. However, its pathogenesis remains poorly understood and attempts at prevention have met with partial success at best. As in other inflammatory states, the transcription factor NF Kappa B (NFkB) is thought to play a key role in the sequence of events leading to the development of pancreatitis. We hypothesized that blocking NFkB activation by intraductal instillation of a potent inhibitor, gliotoxin, may prevent the development of ERCP related pancreatitis. Methods: We studied the effect of intraductal instillation of gliotoxin in a dog model of ECRP induced pancreatitis. In an ongoing study, 6 dogs were randomized in a blinded fashion to receive either placebo or gliotoxin (0.1 mg/kg) intraductally. Pancreatitis was induced by a combination of forceful retrograde injection of contrast material and sphincterotomy as previously described. 24 hours later, dogs were sacrificed, and their pancreata were harvested and graded for histopathological changes of pancreatitis. Results: All dogs survived the experiments for 24 hours. At necropsy, changes of moderate to severe pancreatitis including edema, necrosis, inflammation, vacuolization and hemorrhage were observed in all dogs. Inflammation scores tended to be higher in the gliotoxin group (3.9 versus 3; P = 0.06). Conclusions: These results are consistent with studies of secretagogue induced models of pancreatitis where NFkB activation is felt to induce a self-defending genetic program before the onset of cellular injury, which might prevent higher degrees of damage of pancreatic acinar cells (Gastroenterology 1999; 116:420-430). Our findings suggest that inhibition of NFkB in pancreatitis may have worsened inflammation, thus rendering this an unsuitable strategy for prevention of ERCP induced pancreatitis. Acute pancreatitis is a relatively common and potentially serious complication of ERCP and related interventions. However, its pathogenesis remains poorly understood and attempts at prevention have met with partial success at best. As in other inflammatory states, the transcription factor NF Kappa B (NFkB) is thought to play a key role in the sequence of events leading to the development of pancreatitis. We hypothesized that blocking NFkB activation by intraductal instillation of a potent inhibitor, gliotoxin, may prevent the development of ERCP related pancreatitis. Methods: We studied the effect of intraductal instillation of gliotoxin in a dog model of ECRP induced pancreatitis. In an ongoing study, 6 dogs were randomized in a blinded fashion to receive either placebo or gliotoxin (0.1 mg/kg) intraductally. Pancreatitis was induced by a combination of forceful retrograde injection of contrast material and sphincterotomy as previously described. 24 hours later, dogs were sacrificed, and their pancreata were harvested and graded for histopathological changes of pancreatitis. Results: All dogs survived the experiments for 24 hours. At necropsy, changes of moderate to severe pancreatitis including edema, necrosis, inflammation, vacuolization and hemorrhage were observed in all dogs. Inflammation scores tended to be higher in the gliotoxin group (3.9 versus 3; P = 0.06). Conclusions: These results are consistent with studies of secretagogue induced models of pancreatitis where NFkB activation is felt to induce a self-defending genetic program before the onset of cellular injury, which might prevent higher degrees of damage of pancreatic acinar cells (Gastroenterology 1999; 116:420-430). Our findings suggest that inhibition of NFkB in pancreatitis may have worsened inflammation, thus rendering this an unsuitable strategy for prevention of ERCP induced pancreatitis." @default.
• W2017166446 created "2016-06-24" @default.
• W2017166446 creator A5008668965 @default.
• W2017166446 creator A5014271722 @default.
• W2017166446 creator A5053009487 @default.
• W2017166446 date "2000-04-01" @default.
• W2017166446 modified "2023-09-23" @default.
• W2017166446 title "6982 Effects of intraductal instillation of an nfkb inhibitor, gliotoxin, on ercp induced pancreatitis in a dog model." @default.
• W2017166446 doi "https://doi.org/10.1016/s0016-5107(00)14653-x" @default.
• W2017166446 hasPublicationYear "2000" @default.
• W2017166446 type Work @default.
• W2017166446 sameAs 2017166446 @default.
• W2017166446 citedByCount "0" @default.
• W2017166446 crossrefType "journal-article" @default.
• W2017166446 hasAuthorship W2017166446A5008668965 @default.
• W2017166446 hasAuthorship W2017166446A5014271722 @default.
• W2017166446 hasAuthorship W2017166446A5053009487 @default.
• W2017166446 hasConcept C126322002 @default.
• W2017166446 hasConcept C142724271 @default.
• W2017166446 hasConcept C2775967933 @default.
• W2017166446 hasConcept C2776670229 @default.
• W2017166446 hasConcept C2776914184 @default.
• W2017166446 hasConcept C41260117 @default.
• W2017166446 hasConcept C71924100 @default.
• W2017166446 hasConcept C90924648 @default.
• W2017166446 hasConceptScore W2017166446C126322002 @default.
• W2017166446 hasConceptScore W2017166446C142724271 @default.
• W2017166446 hasConceptScore W2017166446C2775967933 @default.
• W2017166446 hasConceptScore W2017166446C2776670229 @default.
• W2017166446 hasConceptScore W2017166446C2776914184 @default.
• W2017166446 hasConceptScore W2017166446C41260117 @default.
• W2017166446 hasConceptScore W2017166446C71924100 @default.
• W2017166446 hasConceptScore W2017166446C90924648 @default.
• W2017166446 hasIssue "4" @default.
• W2017166446 hasLocation W20171664461 @default.
• W2017166446 hasOpenAccess W2017166446 @default.
• W2017166446 hasPrimaryLocation W20171664461 @default.
• W2017166446 hasRelatedWork W144600971 @default.
• W2017166446 hasRelatedWork W1591978428 @default.
• W2017166446 hasRelatedWork W2025988467 @default.
• W2017166446 hasRelatedWork W2028689006 @default.
• W2017166446 hasRelatedWork W2144563032 @default.
• W2017166446 hasRelatedWork W2357635216 @default.
• W2017166446 hasRelatedWork W2465708202 @default.
• W2017166446 hasRelatedWork W2980718873 @default.
• W2017166446 hasRelatedWork W3119275760 @default.
• W2017166446 hasRelatedWork W32430975 @default.
• W2017166446 hasVolume "51" @default.
• W2017166446 isParatext "false" @default.
• W2017166446 isRetracted "false" @default.
• W2017166446 magId "2017166446" @default.
• W2017166446 workType "article" @default.