Matches in SemOpenAlex for { <https://semopenalex.org/work/W2017169417> ?p ?o ?g. }
Showing items 1 to 78 of
78
with 100 items per page.
- W2017169417 endingPage "1139" @default.
- W2017169417 startingPage "1133" @default.
- W2017169417 abstract "The objective of this work was to study the gastric emptying (GE) of liquids in fasted and sucrose-fed rats with toxic hepatitis induced by acetaminophen. The GE of three test meals (saline, glucose and mayonnaise) was evaluated in Wistar rats. For each meal, the animals were divided into two groups (N = 24 each). Group I was fed a sucrose diet throughout the experiment (66 h) while group II was fasted. Forty-two hours after the start of the experiment, each group was divided into two subgroups (N = 12 each). Subgroup A received a placebo and subgroup B was given acetaminophen (1 g/kg). Twenty-four hours later, the GE of the three test meals was assessed and blood samples were collected to measure the serum levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST) and acetaminophen. In group IB, the mean AST and ALT values were 515 and 263 IU/l, respectively, while for group IIB they were 4014 and 2472 IU/l, respectively. The mean serum acetaminophen levels were higher in group IIB (120 µg/ml) than in group IB (87 µg/ml). The gastric retention values were significantly higher in group IIB than in group IIA for all three test meals: saline, 51 vs 35%; glucose, 52 vs 38% and mayonnaise, 51 vs 29% (median values). The correlation between gastric retention and AST levels was significant (P<0.05) for group IIB for the three test meals: r = 0.73, 0.67 and 0.68 for saline, glucose and mayonnaise, respectively. We conclude that GE is altered in rats with hepatic lesions induced by acetaminophen, and that these alterations may be related to the liver cell necrosis caused by the drug." @default.
- W2017169417 created "2016-06-24" @default.
- W2017169417 creator A5034558933 @default.
- W2017169417 creator A5061763594 @default.
- W2017169417 date "1998-09-01" @default.
- W2017169417 modified "2023-10-12" @default.
- W2017169417 title "Gastric emptying in rats with acetaminophen-induced hepatitis" @default.
- W2017169417 cites W1491170427 @default.
- W2017169417 cites W1945050693 @default.
- W2017169417 cites W2007428434 @default.
- W2017169417 cites W2055135642 @default.
- W2017169417 cites W2082907668 @default.
- W2017169417 cites W2084992276 @default.
- W2017169417 cites W2088388072 @default.
- W2017169417 cites W2100749209 @default.
- W2017169417 cites W4248215213 @default.
- W2017169417 doi "https://doi.org/10.1590/s0100-879x1998000900006" @default.
- W2017169417 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9876280" @default.
- W2017169417 hasPublicationYear "1998" @default.
- W2017169417 type Work @default.
- W2017169417 sameAs 2017169417 @default.
- W2017169417 citedByCount "3" @default.
- W2017169417 countsByYear W20171694172019 @default.
- W2017169417 crossrefType "journal-article" @default.
- W2017169417 hasAuthorship W2017169417A5034558933 @default.
- W2017169417 hasAuthorship W2017169417A5061763594 @default.
- W2017169417 hasBestOaLocation W20171694171 @default.
- W2017169417 hasConcept C126322002 @default.
- W2017169417 hasConcept C134018914 @default.
- W2017169417 hasConcept C142724271 @default.
- W2017169417 hasConcept C185592680 @default.
- W2017169417 hasConcept C204787440 @default.
- W2017169417 hasConcept C27081682 @default.
- W2017169417 hasConcept C2777397205 @default.
- W2017169417 hasConcept C2778345441 @default.
- W2017169417 hasConcept C2778722691 @default.
- W2017169417 hasConcept C2779422922 @default.
- W2017169417 hasConcept C3020479747 @default.
- W2017169417 hasConcept C42219234 @default.
- W2017169417 hasConcept C71924100 @default.
- W2017169417 hasConcept C90924648 @default.
- W2017169417 hasConceptScore W2017169417C126322002 @default.
- W2017169417 hasConceptScore W2017169417C134018914 @default.
- W2017169417 hasConceptScore W2017169417C142724271 @default.
- W2017169417 hasConceptScore W2017169417C185592680 @default.
- W2017169417 hasConceptScore W2017169417C204787440 @default.
- W2017169417 hasConceptScore W2017169417C27081682 @default.
- W2017169417 hasConceptScore W2017169417C2777397205 @default.
- W2017169417 hasConceptScore W2017169417C2778345441 @default.
- W2017169417 hasConceptScore W2017169417C2778722691 @default.
- W2017169417 hasConceptScore W2017169417C2779422922 @default.
- W2017169417 hasConceptScore W2017169417C3020479747 @default.
- W2017169417 hasConceptScore W2017169417C42219234 @default.
- W2017169417 hasConceptScore W2017169417C71924100 @default.
- W2017169417 hasConceptScore W2017169417C90924648 @default.
- W2017169417 hasIssue "9" @default.
- W2017169417 hasLocation W20171694171 @default.
- W2017169417 hasLocation W20171694172 @default.
- W2017169417 hasLocation W20171694173 @default.
- W2017169417 hasOpenAccess W2017169417 @default.
- W2017169417 hasPrimaryLocation W20171694171 @default.
- W2017169417 hasRelatedWork W2009877402 @default.
- W2017169417 hasRelatedWork W2011598966 @default.
- W2017169417 hasRelatedWork W2012525570 @default.
- W2017169417 hasRelatedWork W2025813201 @default.
- W2017169417 hasRelatedWork W2054119993 @default.
- W2017169417 hasRelatedWork W2056503472 @default.
- W2017169417 hasRelatedWork W2071934027 @default.
- W2017169417 hasRelatedWork W2134786031 @default.
- W2017169417 hasRelatedWork W2152464088 @default.
- W2017169417 hasRelatedWork W2748952813 @default.
- W2017169417 hasVolume "31" @default.
- W2017169417 isParatext "false" @default.
- W2017169417 isRetracted "false" @default.
- W2017169417 magId "2017169417" @default.
- W2017169417 workType "article" @default.