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• W2017170711 abstract "Abstract Phenethyl isothiocyanate (PEITC), a constituent of many cruciferous vegetables, is well known to have versatile physiological activities, including chemopreventive effects. On the other hand, its anti‐inflammatory effects are poorly reported. Nitric oxide (NO) is associated with a wide variety of inflammatory diseases. In this study, we investigated the effects of PEITC on NO production in LPS‐activated peritoneal macrophages from ICR mice. The signaling pathway of LPS‐induced NO production was examined using neutralizing antibodies [anti‐interferon (IFN)‐γ and anti‐interleukin (IL‐12)] and specific protein kinase inhibitors, as well as others. The activity of PEITC toward NOx production was assessed in mice that received LPS via intraperitoneal administration. The neutralizing antibody of anti‐IFN‐γ, but not anti‐IL‐12, suppressed LPS‐induced NO production by 90%. LY294002, a specific inhibitor of phosphoinositide‐3‐kinase, suppressed Akt and IFN‐ γ mRNA expression up‐regulated by LPS, whereas PEITC exhibited a similar inhibition profile. Furthermore, oral administration of PEITC significantly suppressed the serum concentration of NOx in ICR mice. Our results suggest that PEITC suppresses LPS‐induced NO production via inhibition of Akt activation and the resultant decrease in expression of IFN‐γ. This is one of the first reports to demonstrate a marked anti‐inflammatory effect of PEITC following its oral administration." @default.
• W2017170711 created "2016-06-24" @default.
• W2017170711 creator A5007681764 @default.
• W2017170711 creator A5016747998 @default.
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• W2017170711 date "2010-09-01" @default.
• W2017170711 modified "2023-09-25" @default.
• W2017170711 title "Phenethyl isothiocyanate suppresses nitric oxide production<i>via</i>inhibition of phosphoinositide 3-kinase/Akt-induced IFN-γ secretion in LPS-activated peritoneal macrophages" @default.
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• W2017170711 doi "https://doi.org/10.1002/mnfr.200900318" @default.
• W2017170711 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20229527" @default.
• W2017170711 hasPublicationYear "2010" @default.
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