FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2017171638> ?p ?o ?g. }

• W2017171638 endingPage "1287" @default.
• W2017171638 startingPage "1278" @default.
• W2017171638 abstract "Summary Infective endocarditis is a life threatening disease caused by a bacterial infection of the endocardial surfaces of the heart. The oral pathogen, Streptococcus gordonii is amongst the most common pathogens isolated from infective endocarditis patients. Previously we identified a novel cell wall protein expressed on S. gordonii called platelet adherence protein A (PadA) that specifically interacts with platelet GPIIb/IIIa. The interaction between PadA and GPIIb/IIIa resulted in firm platelet adhesion, dense granule secretion and platelet spreading on immobilised S. gordonii. This study set out to identify specific motifs on the PadA protein that interacts with platelet GPIIb/IIIa. Proteomic analysis of the PadA protein identified two short amino acid motifs which have been previously shown to be important for fibrinogen binding to GPIIb/IIIa and contributing to the generation of outside-in signalling. Site directed mutagenesis on the PadA protein in which 454AGD was substituted to AAA, and the 383RGT was substituted to AAA suggests the RGT motif has no role in supporting platelet adhesion however plays a role in dense granule secretion and platelet spreading. In contrast to this the AGD motif has no role to play in supporting firm platelet adhesion or dense granule secretion however plays a role in platelet spreading. These results suggest that multiple sites on S. gordonii PadA interact with GPIIb/IIIa to mediate a number of platelet responses that likely contribute to the thrombotic complications of infective endocarditis." @default.
• W2017171638 created "2016-06-24" @default.
• W2017171638 creator A5008465068 @default.
• W2017171638 creator A5036602050 @default.
• W2017171638 creator A5051876886 @default.
• W2017171638 creator A5060768807 @default.
• W2017171638 creator A5074582341 @default.
• W2017171638 creator A5082282820 @default.
• W2017171638 creator A5088693707 @default.
• W2017171638 date "2013-01-01" @default.
• W2017171638 modified "2023-10-16" @default.
• W2017171638 title "Multiple sites on Streptococcus gordonii surface protein PadA bind to platelet GPIIbIIIa" @default.
• W2017171638 cites W1519162499 @default.
• W2017171638 cites W1555561206 @default.
• W2017171638 cites W1966022051 @default.
• W2017171638 cites W1970483666 @default.
• W2017171638 cites W1982474751 @default.
• W2017171638 cites W1982536372 @default.
• W2017171638 cites W1983659762 @default.
• W2017171638 cites W1986586769 @default.
• W2017171638 cites W1990617987 @default.
• W2017171638 cites W1995601334 @default.
• W2017171638 cites W1997729699 @default.
• W2017171638 cites W2016236015 @default.
• W2017171638 cites W2030490295 @default.
• W2017171638 cites W2030696036 @default.
• W2017171638 cites W2035866851 @default.
• W2017171638 cites W2039012502 @default.
• W2017171638 cites W2043558173 @default.
• W2017171638 cites W2062568510 @default.
• W2017171638 cites W2065757518 @default.
• W2017171638 cites W2068628853 @default.
• W2017171638 cites W2075067323 @default.
• W2017171638 cites W2075995685 @default.
• W2017171638 cites W2081645084 @default.
• W2017171638 cites W2089068740 @default.
• W2017171638 cites W2090501412 @default.
• W2017171638 cites W2108801742 @default.
• W2017171638 cites W2115585275 @default.
• W2017171638 cites W2119483434 @default.
• W2017171638 cites W2120151328 @default.
• W2017171638 cites W2129310835 @default.
• W2017171638 cites W2135173846 @default.
• W2017171638 cites W2137968098 @default.
• W2017171638 cites W2138162801 @default.
• W2017171638 cites W2147987490 @default.
• W2017171638 cites W2165125063 @default.
• W2017171638 cites W2243662402 @default.
• W2017171638 cites W4211013927 @default.
• W2017171638 doi "https://doi.org/10.1160/th13-07-0580" @default.
• W2017171638 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4037785" @default.
• W2017171638 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24136582" @default.
• W2017171638 hasPublicationYear "2013" @default.
• W2017171638 type Work @default.
• W2017171638 sameAs 2017171638 @default.
• W2017171638 citedByCount "15" @default.
• W2017171638 countsByYear W20171716382014 @default.
• W2017171638 countsByYear W20171716382015 @default.
• W2017171638 countsByYear W20171716382016 @default.
• W2017171638 countsByYear W20171716382017 @default.
• W2017171638 countsByYear W20171716382018 @default.
• W2017171638 countsByYear W20171716382019 @default.
• W2017171638 countsByYear W20171716382023 @default.
• W2017171638 crossrefType "journal-article" @default.
• W2017171638 hasAuthorship W2017171638A5008465068 @default.
• W2017171638 hasAuthorship W2017171638A5036602050 @default.
• W2017171638 hasAuthorship W2017171638A5051876886 @default.
• W2017171638 hasAuthorship W2017171638A5060768807 @default.
• W2017171638 hasAuthorship W2017171638A5074582341 @default.
• W2017171638 hasAuthorship W2017171638A5082282820 @default.
• W2017171638 hasAuthorship W2017171638A5088693707 @default.
• W2017171638 hasBestOaLocation W20171716382 @default.
• W2017171638 hasConcept C126322002 @default.
• W2017171638 hasConcept C185592680 @default.
• W2017171638 hasConcept C203014093 @default.
• W2017171638 hasConcept C2778663903 @default.
• W2017171638 hasConcept C2780176578 @default.
• W2017171638 hasConcept C2780368718 @default.
• W2017171638 hasConcept C3018697912 @default.
• W2017171638 hasConcept C49039625 @default.
• W2017171638 hasConcept C501593827 @default.
• W2017171638 hasConcept C55493867 @default.
• W2017171638 hasConcept C71924100 @default.
• W2017171638 hasConcept C86803240 @default.
• W2017171638 hasConcept C89423630 @default.
• W2017171638 hasConcept C89560881 @default.
• W2017171638 hasConcept C95444343 @default.
• W2017171638 hasConceptScore W2017171638C126322002 @default.
• W2017171638 hasConceptScore W2017171638C185592680 @default.
• W2017171638 hasConceptScore W2017171638C203014093 @default.
• W2017171638 hasConceptScore W2017171638C2778663903 @default.
• W2017171638 hasConceptScore W2017171638C2780176578 @default.
• W2017171638 hasConceptScore W2017171638C2780368718 @default.
• W2017171638 hasConceptScore W2017171638C3018697912 @default.
• W2017171638 hasConceptScore W2017171638C49039625 @default.
• W2017171638 hasConceptScore W2017171638C501593827 @default.
• W2017171638 hasConceptScore W2017171638C55493867 @default.
• W2017171638 hasConceptScore W2017171638C71924100 @default.

• next