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• W2017172550 abstract "Skin cancer is the most common cancer that occurs in the United States, with more than 1 million new cases each year. There has been interest in the relationship between vitamin A and cancer since the 1920s, when hypovitaminosis A was related to both epithelial changes reminiscent of malignancy and to stomach cancer in rats. During the 1960s and 1970s, there was great activity in the development of synthetic retinoids for cancer treatment and prevention. New indications for retinoids in the 1990s, such as the use of systemic tretinoin for acute promyelocytic leukemia, facilitated a resurgence of interest in the development of retinoids for use in the chemoprevention and/or treatment of a wide variety of malignancies. 1 DiGiovanna JJ. Retinoids for the future: oncology. J Am Acad Dermatol. 1992; 27: S34-S37 Abstract Full Text PDF PubMed Scopus (17) Google Scholar Research to date indicates that retinoids are of limited efficacy for the treatment of existing skin cancers. 2 Peck GL DiGiovanna JJ Sarnoff DS et al. Treatment and prevention of basal cell carcinoma with oral isotretinoin. J Am Acad Dermatol. 1988; 19: 176-185 Abstract Full Text PDF PubMed Scopus (102) Google Scholar However, retinoids appear to have chemopreventive effects. This observation led to studies that assessed the ability of retinoids to prevent cancers in patients at high risk for the development of large numbers of skin cancers. Although most of the studies included small numbers of subjects, minimizing the opportunity for definitive conclusions, there appears to be a therapeutic benefit within these populations. High-dose isotretinoin (2 mg/kg/day) has been used in patients with xeroderma pigmentosum (XP) and nevoid basal cell carcinoma (NBCC) syndrome 3 Peck GL Gross EG Butkus D DiGiovanna JJ. Chemoprevention of basal cell carcinoma with isotretinoin. J Am Acad Dermatol. 1982; 6: 815-823 Abstract Full Text PDF PubMed Scopus (71) Google Scholar , 4 Moshell AN. Prevention of skin cancer in xeroderma pigmentosum with oral isotretinoin. Cutis. 1989; 43: 485-490 PubMed Google Scholar , 5 Kraemer KH DiGiovanna JJ Moshell AN Tarone RE Peck GL. Prevention of skin cancer in xeroderma pigmentosum with the use of oral isotretinoin. N Engl J Med. 1988; 318: 1633-1637 Crossref PubMed Scopus (488) Google Scholar ; these studies consistently reported a pattern of cancer suppression during treatment followed by reversion to the baseline state after completion of therapy. 6 Kraemer KH DiGiovanna JJ Peck GL. Chemopreven-tion of skin cancer in xeroderma pigmentosum. J Dermatol. 1992; 19: 715-718 Crossref PubMed Scopus (87) Google Scholar" @default.
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• W2017172550 date "1998-08-01" @default.
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• W2017172550 title "Retinoid chemoprevention in the high-risk patient" @default.
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• W2017172550 doi "https://doi.org/10.1016/s0190-9622(98)70451-7" @default.
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