Matches in SemOpenAlex for { <https://semopenalex.org/work/W2017173637> ?p ?o ?g. }
- W2017173637 endingPage "532" @default.
- W2017173637 startingPage "514" @default.
- W2017173637 abstract "Tuberculosis (TB) remains a major health threat, killing nearly 2 million individuals around this globe, annually. The only vaccine, developed almost a century ago, provides limited protection only during childhood. After decades without the introduction of new antibiotics, several candidates are currently undergoing clinical investigation. Curing TB requires prolonged combination of chemotherapy with several drugs. Moreover, monitoring the success of therapy is questionable owing to the lack of reliable biomarkers. To substantially improve the situation, a detailed understanding of the cross-talk between human host and the pathogen Mycobacterium tuberculosis (Mtb) is vital. Principally, the enormous success of Mtb is based on three capacities: first, reprogramming of macrophages after primary infection/phagocytosis to prevent its own destruction; second, initiating the formation of well-organized granulomas, comprising different immune cells to create a confined environment for the host-pathogen standoff; third, the capability to shut down its own central metabolism, terminate replication, and thereby transit into a stage of dormancy rendering itself extremely resistant to host defense and drug treatment. Here, we review the molecular mechanisms underlying these processes, draw conclusions in a working model of mycobacterial dormancy, and highlight gaps in our understanding to be addressed in future research." @default.
- W2017173637 created "2016-06-24" @default.
- W2017173637 creator A5014291323 @default.
- W2017173637 creator A5069152440 @default.
- W2017173637 date "2012-05-01" @default.
- W2017173637 modified "2023-10-15" @default.
- W2017173637 title "<i>Mycobacterium tuberculosis</i>: success through dormancy" @default.
- W2017173637 cites W1515325537 @default.
- W2017173637 cites W1526489492 @default.
- W2017173637 cites W1532965680 @default.
- W2017173637 cites W1548443534 @default.
- W2017173637 cites W1553565832 @default.
- W2017173637 cites W1560571961 @default.
- W2017173637 cites W181645241 @default.
- W2017173637 cites W1843137073 @default.
- W2017173637 cites W1864461701 @default.
- W2017173637 cites W1870140643 @default.
- W2017173637 cites W1927671826 @default.
- W2017173637 cites W1938998220 @default.
- W2017173637 cites W1964141703 @default.
- W2017173637 cites W1966023562 @default.
- W2017173637 cites W1966311044 @default.
- W2017173637 cites W1966448483 @default.
- W2017173637 cites W1968652010 @default.
- W2017173637 cites W1969623044 @default.
- W2017173637 cites W1972269365 @default.
- W2017173637 cites W1974234256 @default.
- W2017173637 cites W1975173458 @default.
- W2017173637 cites W1975460230 @default.
- W2017173637 cites W1975462016 @default.
- W2017173637 cites W1986106712 @default.
- W2017173637 cites W1989883893 @default.
- W2017173637 cites W1991233072 @default.
- W2017173637 cites W1996520342 @default.
- W2017173637 cites W2000117355 @default.
- W2017173637 cites W2000206958 @default.
- W2017173637 cites W2000764396 @default.
- W2017173637 cites W2001414564 @default.
- W2017173637 cites W2002423236 @default.
- W2017173637 cites W2005861260 @default.
- W2017173637 cites W2007097682 @default.
- W2017173637 cites W2007184315 @default.
- W2017173637 cites W2010053743 @default.
- W2017173637 cites W2013041999 @default.
- W2017173637 cites W2015648468 @default.
- W2017173637 cites W2019431372 @default.
- W2017173637 cites W2020201637 @default.
- W2017173637 cites W2020224454 @default.
- W2017173637 cites W2022159086 @default.
- W2017173637 cites W2022725992 @default.
- W2017173637 cites W2024455490 @default.
- W2017173637 cites W2026482455 @default.
- W2017173637 cites W2028536701 @default.
- W2017173637 cites W2029470863 @default.
- W2017173637 cites W2032303370 @default.
- W2017173637 cites W2033333560 @default.
- W2017173637 cites W2033541022 @default.
- W2017173637 cites W2036032145 @default.
- W2017173637 cites W2036167259 @default.
- W2017173637 cites W2036420717 @default.
- W2017173637 cites W2040519812 @default.
- W2017173637 cites W2040544951 @default.
- W2017173637 cites W2040584799 @default.
- W2017173637 cites W2045219246 @default.
- W2017173637 cites W2046954682 @default.
- W2017173637 cites W2047330514 @default.
- W2017173637 cites W2047686077 @default.
- W2017173637 cites W2048961513 @default.
- W2017173637 cites W2050642108 @default.
- W2017173637 cites W2051114496 @default.
- W2017173637 cites W2052902273 @default.
- W2017173637 cites W2054822772 @default.
- W2017173637 cites W2058137293 @default.
- W2017173637 cites W2061721395 @default.
- W2017173637 cites W2062173234 @default.
- W2017173637 cites W2062555948 @default.
- W2017173637 cites W2063986522 @default.
- W2017173637 cites W2064224579 @default.
- W2017173637 cites W2065542724 @default.
- W2017173637 cites W2065903108 @default.
- W2017173637 cites W2066033587 @default.
- W2017173637 cites W2066135800 @default.
- W2017173637 cites W2066515050 @default.
- W2017173637 cites W2069179741 @default.
- W2017173637 cites W2073412176 @default.
- W2017173637 cites W2073663438 @default.
- W2017173637 cites W2074862238 @default.
- W2017173637 cites W2076631817 @default.
- W2017173637 cites W2081444617 @default.
- W2017173637 cites W2082405038 @default.
- W2017173637 cites W2083227510 @default.
- W2017173637 cites W2084777656 @default.
- W2017173637 cites W2085128107 @default.
- W2017173637 cites W2088101132 @default.
- W2017173637 cites W2090197974 @default.
- W2017173637 cites W2092325349 @default.
- W2017173637 cites W2094104389 @default.
- W2017173637 cites W2096440966 @default.